[HTML][HTML] Plant high-affinity potassium (HKT) transporters involved in salinity tolerance: structural insights to probe differences in ion selectivity

S Waters, M Gilliham, M Hrmova - International journal of molecular …, 2013 - mdpi.com
… the current structural and functional knowledge relating to plant HKTs and how their structural
features … Our goal is to present how knowledge of the structure of HKT proteins is helpful in …

Structural insights into the high affinity binding of cardiotonic steroids to the Na+, K+-ATPase

L Yatime, M Laursen, JP Morth, M Esmann… - Journal of structural …, 2011 - Elsevier
structure of the pig kidney Na + ,K + -ATPase in its phosphorylated form stabilized by high
affinity … This structure differs from the previously reported low affinity complex with potassium. …

Structural insights into the mechanism of high-affinity binding of ochratoxin A by a DNA aptamer

G Xu, J Zhao, H Yu, C Wang, Y Huang… - Journal of the …, 2022 - ACS Publications
… The present research contributes to a deeper insight of aptamer molecular recognition,
reveals structural basis of the high-affinity binding of aptamers, and provides a foundation for …

Structural insights into the interactions between human IgE and its high affinity receptor FcεRI

BA Wurzburg, TS Jardetzky - Molecular immunology, 2002 - Elsevier
… The interaction of IgE antibodies with the high affinity IgE receptor, FcεRI, is a key step in
the initiation of anti-parasitic immunity and allergic reactions. Recent structural studies of the …

Cell‐permeable highaffinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors

M Kuschak, V Namasivayam, M Rafehi… - British journal of …, 2020 - Wiley Online Library
… Cell-permeable high-affinity tracers for G q proteins provide structural insights, reveal … G q
-specific high-affinity chemical probes for detection and quantification with high accuracy and …

Structural insights into the evolution of an antibody combining site

GJ Wedemayer, PA Patten, LH Wang, PG Schultz… - Science, 1997 - science.org
… These structures are compared with the corresponding crystal structures of the affinity-matured
antibody, 48G7, which has a 30,000 times higher affinity for hapten as a result of nine …

Structural insights into a high affinity nanobody: antigen complex by homology modelling

PD Skottrup - Journal of Molecular Graphics and Modelling, 2017 - Elsevier
… of the high affinity VHH and to understand how and where the nanobody binds on RgpB,
this paper describes the structural modelling of the high affinity VHH7:RgpB complex. …

[HTML][HTML] Structural insights on the pamoic acid and the 8 kDa domain of DNA polymerase beta complex: towards the design of higher-affinity inhibitors

C Hazan, F Boudsocq, V Gervais, O Saurel… - BMC Structural …, 2008 - Springer
… specific inhibitors, its affinity (low micromolar) has to be improved. Structural insights in the
… acid are prerequisites to improve the ligand affinity by applying the fragment-based strategy. …

[HTML][HTML] Insights into the structural basis of antibody affinity maturation from next-generation sequencing

AK Mishra, RA Mariuzza - Frontiers in immunology, 2018 - frontiersin.org
Affinity maturation is the process whereby the immune system generates antibodies of
higher affinities during a response to antigen. It is unique in being the only evolutionary …

Structural insights for the design of new PPARgamma partial agonists with high binding affinity and low transactivation activity

L Guasch, E Sala, C Valls, M Blay, M Mulero… - Journal of computer …, 2011 - Springer
… a high binding affinity to inhibit phosphorylation at Ser273. We use several structure activity
… Despite the fact that interactions with arm I increase the binding affinity, this region should …