… Mean DCF levels were 26% higher with high glucose and BKA than with high glucose alone.
Under control conditions, DCF levels were 31% higher in the presence of BKA (mean of 3 …

… To understand the mechanism of high glucose-induced cell dysfunction, we examined
high glucose-induced alteration in the mRNA level of several respiratory chain subunits. The …

… However, their roles in mitochondrial dysfunction of white … high glucose (25 mM), high free
fatty acids (FFAs, 1 mM), or a combination of both high glucose + high FFAs on mitochondrial …

… controlled blood glucose levels. The potential role of inherited, mild mitochondrial dysfunction
in … Here, we first discuss normal blood glucose control and its perturbations consequent to …

… promote mitochondrial dysfunction. … mitochondrial fragmentation, and to better understand
mechanisms involving compromised mitophagy. Our finding that mitochondrial dysfunction …

… 24 and 48 h after high glucose exposure. Our results indicate that high glucose first induced
superoxide generation and hyperpolarization in the mitochondria, followed by a secondary …

… of ROS provoked by high glucose (HG) environment triggered mitochondrial dysfunction,
inflammatory … Our results demonstrated that elevated glucose level in keratinoctes, increase the …

… As mitochondrial dysfunction could lead to the accumulation of ceramides [31], we aimed to
… -2 genes, that code for ceramide synthases in glucose-fed worms. It has been described that …

… to address the potential relationship between mitochondrial dysfunction, high glucose and
O-GlcNAc. Our results suggest that high-glucose-induced mitochondrial dysfunction can occur …

… In particular, changes in mitochondrial morphology, mitochondrial membrane potential …
in which high glucose influences two disparate cellular organelles, mitochondria and ER, in …