… We report that treatment of EPCs with high glucose for 3 days … , this was associated with
reduced SIRT1 expression levels and … with SIRT1 inhibitor, nicotinamide, or activator, resveratrol. …

… that SIRT1 might play a role in mediating high glucose-… that high glucose significantly
downregulated SIRT1 expression on … Next, we pretreated cells with SIRT1 activator SRT1720 or its …

… mM glucose for 72 h to establish an in vitro high glucose (HG) condition model, and then
additional groups co-treated with or without DAPA before glucose … , and SIRT1 expression were …

… By up-regulating Sirt1, resveratrol (a Sirt1 activator) may inhibit oxidative stress and
inflammatory responses in vascular endothelial cells, protecting them from apoptosis (16). Studies …

… effects of an SIRT1 activator and an inhibitor on autophagy in hyperglycemia-activated MCs.
… These findings indicate that SIRT1 activates autophagy in hyperglycemia-activated MCs. …

… from high glucose or high fat associated with activating Sirt1. … cells against high glucose
or high fat via Sirt1 activation. To … effects of SAB on high glucose or high fat-induced HUVEC …

… that anagliptin treatment significantly abolished high glucose- induced maturation of … high
glucose- induced reduction of SIRT1 expression. Silencing of SIRT1 by transfection with SIRT1 …

… cells (HUVECs) exposed to high glucose conditions and against diabetes-accelerated …
high glucose and attenuated diabetes-accelerated atherosclerosis by Sirt1-mediated activation …

… Metformin effects are partially restored by the SIRT1 activator SRT2183 in cells overexpressing
p53. We next tested whether SIRT1 activation in cells overexpressing p53 would restore …

… high glucose-induced decreasing of SIRT1 was reversed with RV. Then, we detected the effect
of activation of SIRT1 on … The most important finding of this work is that activation of SIRT1 …