[HTML][HTML] Emerging concepts in PD-1 checkpoint biology

KE Pauken, JA Torchia, A Chaudhri, AH Sharpe… - Seminars in …, 2021 - Elsevier
… concepts in the PD-1 pathway, including (1) the impact of PD-1 inhibitors on … PD-L2 is
higher than PD-L1, its lower expression levels gives a competitive advantage to PD-L1-PD-1

[HTML][HTML] PD-1/PD-L1 pathway: current researches in cancer

Y Han, D Liu, L Li - American journal of cancer research, 2020 - ncbi.nlm.nih.gov
… that NKX2-1-AS1 inhibits the expression of CD274 (PD-L1) mRNA and protein in lung cancer
and high levels of NKX2-1-AS1 are crucial for maintaining low levels of PD-L1 expression, …

PD1/PD‐L1 immune checkpoint: potential target for cancer therapy

FK Dermani, P Samadi, G Rahmani… - Journal of cellular …, 2019 - Wiley Online Library
… Tumors cells can be distinguished by their lack of PD-L1 and have high levels of TILs, or
vice versa. On the other hand, tumors can acquire expression of both PDL1 and high levels of …

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

EF Tewalt, JN Cohen, SJ Rouhani… - Blood, The Journal …, 2012 - ashpublications.org
… Thus, presentation of antigen by LECs leads to more rapid and higher level PD-1 … To
determine whether rapid, high-level expression of PD-1 on FH cells was because of lack of …

Tumor antigen–specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

M Ahmadzadeh, LA Johnson… - Blood, The Journal …, 2009 - ashpublications.org
… In the present study, we report the expression of high levels of PD-1 on a large proportion
of T cells infiltrating into tumors compared with those in normal tissue and peripheral blood in …

High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

V Kasprowicz, J Schulze zur Wiesch, T Kuntzen… - Journal of …, 2008 - Am Soc Microbiol
… We observed high levels of PD-1 expression (60 to 100%) … By analyzing on the basis of
percent positive PD-1 expression, … However, the majority of HCV-specific T cells remained PD-1

[HTML][HTML] Biomarkers of response to PD-1/PD-L1 inhibition

SM Vareki, C Garrigós, I Duran - Critical reviews in oncology/hematology, 2017 - Elsevier
… -PD-1/PD-L1 agents. However, in the case of Ipilimumab, assessment of patients’ ANC and
dNLR levels … (ICC) with high NLR had significantly higher percentage of PD-1 positive T cells …

[HTML][HTML] Role of the PD-1 pathway in the immune response

LV Riella, AM Paterson, AH Sharpe… - American Journal of …, 2012 - Elsevier
high levels of PD-1 (15,41), and PD-L1 and PD-L2 are upregulated on germinal center B cells
(42). PD-1 … regulation of the germinal center B cell response; PD-1 −/− BALB/c mice have a …

PD-1/PD-L1 in disease

N Kuol, L Stojanovska, K Nurgali… - Immunotherapy, 2018 - Taylor & Francis
… Cancer cells can express high levels of PD-L1, which by binding to PD-1 expressed by T
cells initiates an inhibitory signaling network that switches off activated T cells and results in T …

[HTML][HTML] Patterns and prognostic relevance of PD-1 and PD-L1 expression in colorectal carcinoma

LH Lee, MS Cavalcanti, NH Segal, JF Hechtman… - Modern Pathology, 2016 - Elsevier
… criteria to separate tumors into high and low PD-L1 and PD-1 expression categories. '… -L1
was no longer significant when the tumors did not have high levels PD-1-positive tumor-…