The histone demethylase jumonji coordinates cellular senescence including secretion of neural stem cell–attracting cytokines

PM Perrigue, ME Silva, CD Warden, NL Feng… - Molecular Cancer …, 2015 - AACR
… cytokines have been linked to homing of neural stem cells and other stem cells to tumor loci.
… Prominent among them are neural stem cells (NSC) and other stem cells that intrinsically …

Jumonji family histone demethylases in neural development

R Fueyo, MA García, MA Martínez-Balbás - Cell and tissue research, 2015 - Springer
… The central nervous system (CNS) is formed by different cell types that are generated during
neural development. Neural progenitor cells (NPCs) proliferate to maintain their population, …

SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron

K Jepsen, D Solum, T Zhou, RJ McEvilly, HJ Kim… - Nature, 2007 - nature.com
… represses expression of the jumonji-domain containing gene … as a histone H3 trimethyl
K27 demethylase and which is … histone H3K27me3 modification by the histone demethylase

Epigenetic regulation in neural stem cell differentiation

B Juliandi, M Abematsu… - Development, growth & …, 2010 - Wiley Online Library
… (an H3K27me3 demethylase), which belongs to the jumonji … and histone modification status
during stem cell development… stem cells (mESCs) into neural stem cells (NSCs) and neural

Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3

JW Jung, S Lee, MS Seo, SB Park, A Kurtz… - Cellular and Molecular …, 2010 - Springer
… , and JMJD3 histone lysine demethylase decreased in senescent … INK4A depends on
demethylation at lysine 27 of histone H3 (… histone marker known as a target site for EZH2 histone

Histone Demethylase Jumonji D3 (JMJD3) as a Tumor Suppressor by Regulating p53 Protein Nuclear Stabilization

CI Ene, L Edwards, G Riddick, M Baysan, K Woolard… - PloS one, 2012 - journals.plos.org
… acid (RA) on JMJD3 transcriptional activity during differentiation of mouse neural stem cells
(MsNSC), glioblastoma stem cells (GSCs) and serum grown U87 malignant glioblastoma …

Functional analysis of histone demethylase Jmjd2b on lipopolysaccharide-treated murine neural stem cells (NSCs)

ND Das, MR Choi, KH Jung, JH Park, HT Lee… - Neurotoxicity …, 2013 - Springer
stem cell line, NE-4C. We found that Jmjd2b, histone-3 lysine-9 di-/tri-methyl (H3K9me2/3)
demethylase, is … Jmjd2 family that is characterized by the catalytic Jumonji C (JmjC) domain. …

Cell-type-specific Jumonji histone demethylase gene expression in the healthy rat CNS: detection by a novel flow cytometry method

SMC Smith, RS Kimyon, JJ Watters - 2014 - journals.sagepub.com
… Our studies were performed on adult cells isolated from the whole brain; stem cells
differentiated in vitro may not accurately reflect identical gene expression levels and patterns of 3-…

Histone demethylase LSD1 regulates neural stem cell proliferation

GQ Sun, K Alzayady, R Stewart, P Ye… - … and cellular biology, 2010 - Taylor & Francis
… In 2005, it was predicted that there exists a second class of histone demethylases that contain
a jumonji C (Jmjc) domain (Citation19), a motif present in many proteins that are known to …

Combined loss of JMJD1A and JMJD1B reveals critical roles for H3K9 demethylation in the maintenance of embryonic stem cells and early embryogenesis

S Kuroki, Y Nakai, R Maeda, N Okashita, M Akiyoshi… - Stem cell reports, 2018 - cell.com
… rapid cell death in embryonic stem cells (ESCs). These results indicate that JMJD1A/JMJD1B-meditated
H3K9 demethylation … Obesity and metabolic syndrome in histone demethylase