… In this chapter, we will introduce various histone methylation marks and their functions on
gene transcription, methyltransferases and demethylases that regulate specific sites of histone …

… of histone proteins regulate a wide variety of cellular processes. Methylation of histone H3K79
and … Both Dot1L and Set1 are activated by prior ubiquitination of histone H2B on K120 in a …

… mammalian spreading system, where the regulation of the methyltransferase has yet to be
explored in a defined biochemical system. Allosteric regulation is an important aspect of many …

… regulation of chromatin structure dynamics and gene expression. Both histone methyltransferase
and histone … of different histone methylation status. The ‘effectors’ which can recognize …

… for specific cohorts of inhibitory histone methyltransferases (HMTs) to … regulated transcription
factors from binding to their target gene promoters and causing constitutive gene activation …

… of the histone polypeptides, the histone tails. Below, we summarize recent advances … histone
methyltransferases, and we discuss histone methylation within the context of other histone …

… methylation plays a role in regulating ERα-dependent gene activation, and we sought to …
activated the expression of several ERα target genes in MCF7 cells, including growth regulation …

… regulated by histone tails and their modification. In this study, we explore the role of … histone
tail-Dnmt3a interaction and provide evidence for allosteric regulation of Dnmt3a by histone …

… regulation and the establishment of heterochromatin. Concomitantly, several families of
histone methyltransferases (… or lysines in histones H3 and H4. Not surprisingly, many of these …

… histone lysine methylation during development. In the first part, we will discuss how histone
lysine methylation facilitates gene activation … selected histone methyltransferases (HMTases). …