1 天前 - … DNA methylation, an epigenetic modification that is crucial for gene regulation. Here,
we investigated whether targeting the dysregulated DNA … adding DNA methyltransferase …

1 天前 - … We sought to reverse these changes using the DNA methyltransferase inhibitor,
decitabine, in 4 DIPG neurosphere cell lines. Treatment with decitabine reversed the entropy …

1 天前 - … mutant histone, which promotes epigenetic dysregulation, leading … DNA
hypomethylation, and a distinct gene expression profile. DIPG cells retain histone methylation at …

2 天前 - … for studying and targeting epigenetic modifications associated with chronic
benign … the critical role that epigenetic machinery, such as DNA methyltransferases (DNMTs), …

7 天前 - … was regulated by epigenetic modification, might … DNA by DNA methyltransferases
(DNMTs) [73]. This change modifies chromatin structure, interactions with DNA proteins, DNA …

8 天前 - … DNA methyltransferase genes and 3 demethylase genes were identified, exposing
epigenetic … could be due to epigenetic changes. Adult leaves displaying the highest overall …

9 天前 - … PHOF-2 can activate a prodrug (pro-procainamide) in situ, which can specifically
inhibit DNA methyltransferase 1 (DNMT1) activity and remodel the epigenetic modification of …

9 天前 - … Epigenetic modifications, such as DNA methylation, can facilitate plastic responses
by … for DNA methyltransferases and forms a covalent bond with carbon 6 of the DNMT. This …

9 天前 - … Moreover, reduced DNA methylation level was associated with reduced
expression of several DNA methyltransferase genes. Compared with those under CK (normal …

9 天前 - … the nucleus, and mediates epigenetic silencing of protein … locus in a DNA
methyltransferase–dependent manner. … Mechanistically, yREX3 acts via epigenetic modification of …