Regulatory mechanisms controlling human hepatocyte nuclear factor 4α gene expression
P Hatzis, I Talianidis - Molecular and cellular biology, 2001 - Taylor & Francis
… expression. Within this region we mapped binding sites for transcription factors HNF-1α and
-β, Sp-1, HNF… mechanisms of how these factors may regulate HNF-4α expression. Moreover, …
-β, Sp-1, HNF… mechanisms of how these factors may regulate HNF-4α expression. Moreover, …
Mammalian hepatocyte differentiation requires the transcription factor HNF-4α
… have demonstrated that HNF-4α is essential for expression of the transcription factors HNF-1α
… Based on these results we propose that HNF-4α acts as a hepatocyte differentiation factor …
… Based on these results we propose that HNF-4α acts as a hepatocyte differentiation factor …
Identification of HNF-4α as a key transcription factor to promote ChREBP expression in response to glucose
J Meng, M Feng, W Dong, Y Zhu, Y Li, P Zhang, L Wu… - Scientific reports, 2016 - nature.com
… factor 4 alpha (HNF-4α) is a key transcription factor for glucose-induced ChREBP-α and
ChREBP-β expression… the effect of suppressing HNF-4α expression on ChREBP transcription, …
ChREBP-β expression… the effect of suppressing HNF-4α expression on ChREBP transcription, …
A distant upstream promoter of the HNF-4α gene connects the transcription factors involved in maturity-onset diabetes of the young
H Thomas, K Jaschkowitz, M Bulman… - Human molecular …, 2001 - academic.oup.com
… of the HNF-4α gene may be important for the expression of slightly different transcription
factors. This interpretation is supported by our previous finding that the transcription factor …
factors. This interpretation is supported by our previous finding that the transcription factor …
[HTML][HTML] Role of hepatocyte nuclear factor 4α (HNF4α) in cell proliferation and cancer
C Walesky, U Apte - Gene expression, 2015 - ncbi.nlm.nih.gov
… Hepatocyte nuclear factor 4α (HNF4α) is an orphan nuclear … Whereas the role of HNF4α in
hepatocyte differentiation is … Recent studies have revealed that HNF4α inhibits proliferation …
hepatocyte differentiation is … Recent studies have revealed that HNF4α inhibits proliferation …
Hepatocyte nuclear factor (HNF) 1 and HNF4 mediate hepatic multidrug resistance protein 2 up-regulation during hepatitis C virus gene expression
I Qadri, M Iwahashi, GA Kullak-Ublick, FR Simon - Molecular pharmacology, 2006 - ASPET
… a homeodomain-containing transcription factor, hepatocyte nuclear factor (HNF) 1, plays a
… gene expression and/or subgenome replication. MRP2 protein and mRNA expression were …
… gene expression and/or subgenome replication. MRP2 protein and mRNA expression were …
Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4α (HNF4α) isoforms in human and rats
S Jiang, T Tanaka, H Iwanari, H Hotta, H Yamashita… - Nuclear receptor, 2003 - Springer
… Hepatocyte nuclear factor-4α (HNF4α; NR2A1) is an orphan … A loss-of-function mutation in
human HNF4α causes one form of … The expression of HNF4α in a variety of tissues has been …
human HNF4α causes one form of … The expression of HNF4α in a variety of tissues has been …
The maturity-onset diabetes of the young (MODY1) transcription factor HNF4α regulates expression of genes required for glucose transport and metabolism
… Hepatocyte nuclear factor 4α (HNF4α) plays a critical role in regulating the expression of …
A nonsense mutation (Q268X) in exon 7 of the HNF4α gene is responsible for an autosomal …
A nonsense mutation (Q268X) in exon 7 of the HNF4α gene is responsible for an autosomal …
Regulation of hepatocyte nuclear factor 4α-mediated transcription
FJ Gonzalez - Drug metabolism and pharmacokinetics, 2008 - Elsevier
… factor 4α (HNF4α, NR2A1) is required for development of the liver and for controlling the
expression of many genes specifically expressed … Among the genes regulated by HNF4α are the …
expression of many genes specifically expressed … Among the genes regulated by HNF4α are the …
Tissue-specific transcription factor HNF4α inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 β-cell line
S Erdmann, S Senkel, T Arndt, B Lucas, J Lausen… - 2007 - degruyter.com
… By establishing cell lines with inducible expression of these target genes, we deduce that
both factors are insufficient to induce apoptosis. We propose that the anti-proliferative and …
both factors are insufficient to induce apoptosis. We propose that the anti-proliferative and …