… serum factors. In addition, we have demonstrated that HNF-4α is essential for expression
of the transcription factors HNF-1α and PXR within the fetal liver. We therefore conclude that …

… Here we report that hepatocyte nuclear factor 4 alpha (HNF-4α) is a key transcription factor
… Ectopic HNF-4α expression increased ChREBP transcription while knockdown of HNF-4α …

… transcription factors HNF-1α, HNF-1β and IPF-1, we propose that the four MODY transcription
factors … network interconnected at the distant upstream P2 promoter of the HNF-4α gene. …

… binding sites for transcription factors HNF-1α and -β, Sp-1, HNF-6, and GATA-6. We
describe two alternative mechanisms of how these factors may regulate HNF-4α expression. …

… of one of two Sp1 transcription factor binding sites, thereby reducing promoter activity by
50% [18]. This study suggested that alterations in the level of HNF-4α gene expression can …

… Hepatocyte nuclear factor 4a (HNF4a) is a tissue-specific transcription factor expressed in
… of these target genes, we deduce that both factors are insufficient to induce apoptosis. We …

… HNF-4α and HNF-1α. We propose that the rapid suppression and reconstitution of liver specific
transcription factor … gene transcription in vivo, and suggest a central role for HNF-4α and …

… Hepatocyte nuclear factor 4α (HNF4α) plays a critical role in regulating the expression of
many genes essential for normal functioning of liver, gut, kidney, and pancreatic islets. A …

… that HNF4α is a widely acting transcription factor in these tissues, consistent with the
observation that it is an unusually abundant and constitutively active transcription factor (11). …

… enhanced by hepatocyte nuclear factor-4α (HNF-4α), acting … was achieved when HIF-1α,
HNF-4, and p300 were … a regulatory transcriptional complex consisting of HIF-1, HNF-…