Hormone-targeted therapy and resistance

C Metcalfe, LS Friedman… - Annual Review of Cancer …, 2018 - annualreviews.org
… While this classical genomic dependency is relevant to most cancers, breast and prostate
cancers are unique in their well-established additional dependence on hormone receptor (HR) …

Endocrine therapy combined with targeted therapy in hormone receptor-positive metastatic breast cancer

L Bian, FR Xu, ZF Jiang - Chinese medical journal, 2020 - mednexus.org
… Increasing numbers of targeted drugs are used in hormone receptortherapy. This study
will systemically review the progress made in endocrine therapy combined with targeted therapy

Endocrine treatment and targeted therapy for hormone receptor–positive, human epidermal growth factor receptor 2–negative metastatic breast cancer: ASCO …

HJ Burstein, MR Somerfield, DL Barton… - Journal of clinical …, 2021 - ascopubs.org
… To update recommendations of the ASCO systemic therapy for hormone receptor (HR)-…
receptor 2 (HER2)-negative, PIK3CA-mutated, ABC, or MBC following prior endocrine therapy

Current landscape of targeted therapy in hormone receptor-positive and HER2-negative breast cancer

S Andrahennadi, A Sami, M Manna, M Pauls… - Current …, 2021 - mdpi.com
therapy is not uncommon. Over the past decades, the emergence of novel targeted therapy
in combination with endocrine therapy … This paper reviews available data of targeted therapy

Current landscape of targeted therapies for hormone-receptor positive, HER2 negative metastatic breast cancer

TJ Ballinger, JB Meier, VM Jansen - Frontiers in oncology, 2018 - frontiersin.org
… in patients with hormone receptor (HR) positive, HER2 negative disease. Endocrine therapy
(ET… generation of targeted therapies for advanced breast cancer. In addition to anti-estrogen …

Targeted therapies overcoming endocrine resistance in hormone receptor-positive breast cancer

K Almstedt, M Schmidt - Breast Care, 2015 - karger.com
… However, the possibility of altered tumour characteristics with a switch of hormone receptor
(… endocrine therapy is the treatment of choice for patients with an advanced hormone receptor-…

Endocrine and targeted therapy for hormone-receptor-positive, HER2-negative advanced breast cancer: insights to sequencing treatment and overcoming resistance …

R El Sayed, L El Jamal, S El Iskandarani, J Kort… - Frontiers in …, 2019 - frontiersin.org
… This review will compare the available endocrine therapy and targeted therapy options for
HR-positive/HER2-negative ABC in postmenopausal women, with some mention of treatment …

… targeted therapy for patients with human epidermal growth factor receptor 2–negative metastatic breast cancer that is either endocrine-pretreated or hormone receptor …

B Moy, RB Rumble, SE Come, NE Davidson… - Journal of Clinical …, 2021 - ascopubs.org
… of nonendocrine agents for patients with hormone receptor–positive but HER2-negative
metastatic breast cancer who are no longer benefiting from endocrine therapy (with or without …

Increased life expectancy as a result of non-hormonal targeted therapies for HER2 or hormone receptor positive metastatic breast cancer: A systematic review and …

RG Koleva-Kolarova, MP Oktora, AL Robijn… - Cancer Treatment …, 2017 - Elsevier
… non-hormonal targeted therapies (TTs) in terms of increase of median progression-free survival
(PFS) and overall survival (OS) in receptor-… on targeted and comparator therapy, receptor

New strategies in metastatic hormone receptor–positive breast cancer: searching for biomarkers to tailor endocrine and other targeted therapies

RC Jankowitz, S Oesterreich, AV Lee… - Clinical Cancer Research, 2017 - AACR
… Although major advances in our understanding of the molecular underpinnings of hormone
receptor–positive (HR + ) breast cancer have led to new therapies that have substantially …