… children. Methods: We conducted a randomized prospective study comparing quinine and
artemether therapies in 90 Nigerian children … children treated with quinine died in the hospital (…

… of artemether and quinine in the treatment of severe malaria in hospitalized children. Study
design… (6) there is an urgent need to identify new forms of therapy for severe and complicated …

… quinine was 11.1 +- 4.8 hours, and the volume of distribution was 139 +_ 0.37 L/kg. To attain
a serum level of 10 l~g/ml quinine, we suggest that children … therapy are also given quinine. …

… This complies with pharmacokinetic studies, which suggests that a loading dose of quinine
reduces the time to reach therapeutic plasma concentrations. Globally, FCT was shorter than …

… children treated with artemether died in the hospital (20.5 percent), as compared with 62 of
the 288 treated with quinine (… The recommended therapy is parenteral quinine, but the case …

… , all children attending the outpatient clinic of the Albert-Schweitzer-Hospital who fulfilled the
… parasite clearance; (4) no antimalarial therapy had been received within the preceding 7 …

… ), and since quinine was readily available, we administered intravenous quinine as a bolus
of … Awareness that quinine may be an alternate therapeutic option could be important in some …

… , as quinine is a drug with a narrow therapeutic … quinine is increased in children with global
malnutrition, we suggest that the administration interval should be reduced in these children …

… quinine is limited and larger trials are required. We compared the safety and efficacy of rectal
quinine compared with intramuscular quinine in children … combination therapy.24 Rectal …

… oral Malarone and to intravenous quinine. Adverse events were … of the patient’s hospital
stay after commencement of therapy. … and quinine were given as a directly observed therapy to …