Cellular host factors for SARS-CoV-2 infection

J Baggen, E Vanstreels, S Jansen, D Daelemans - Nature Microbiology, 2021 - nature.com
CoV-2 life cycle. In this Review, we summarize insights into the proviral host factors that
are required for SARS-CoV… We discuss cellular processes that are important for the SARS-CoV-2 …

Role of host factors in SARS-CoV-2 entry

JP Evans, SL Liu - Journal of Biological Chemistry, 2021 - ASBMB
… findings on the factors governing SARS-CoV-2 … host cell membrane through binding to the
SARS-CoV-2 receptor, angiotensin-converting enzyme 2. We then examined the roles of host

[HTML][HTML] Identification of required host factors for SARS-CoV-2 infection in human cells

Z Daniloski, TX Jordan, HH Wessels, DA Hoagland… - Cell, 2021 - cell.com
… To better understand host-virus genetic dependencies and … screen to identify host factors
required for SARS-CoV-2 viral … loss of each host gene on fitness/response to viral infection. …

Targeting crucial host factors of SARS-CoV-2

AM Tharappel, SK Samrat, Z Li, H Li - ACS infectious diseases, 2020 - ACS Publications
… In this Review, we discuss the role of primary host factors such as the cell receptor … ,
and their pharmacological intervention in the infection of SARS-CoV-2 and related viruses. …

Genetic screens identify host factors for SARS-CoV-2 and common cold coronaviruses

R Wang, CR Simoneau, J Kulsuptrakul, M Bouhaddou… - Cell, 2021 - cell.com
… Finding host factors common to multiple coronaviruses could facilitate the … coronavirus
pandemics. Here, we conducted genome-wide CRISPR screens in cells infected by SARS-CoV-2 …

Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection

J Wei, MM Alfajaro, PC DeWeirdt, RE Hanna… - Cell, 2021 - cell.com
… (MERS-CoV), bat CoV HKU5 expressing the SARS-CoV-1 spike, and vesicular stomatitis
virus (VSV) expressing the SARS-CoV-2 spike. We identified known SARS-CoV-2 host factors, …

Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks

WM Schneider, JM Luna, HH Hoffmann… - Cell, 2021 - cell.com
… an extensive functional catalog of host factors required for infection by SARS-CoV-2 and
three … that highlight pan-CoV and virus-specific host factors through the lens of SARS-CoV-2. …

Virus-host interactome and proteomic survey reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

J Li, M Guo, X Tian, X Wang, X Yang, P Wu, C Liu… - Med, 2021 - cell.com
… 286 host proteins targeted by SARS-CoV-2 and >350 host … with NF-κB-repressing factor
(NKRF) to facilitate interleukin-8 (IL-… host inflammatory response observed in COVID-19 patients. …

Interactomes of SARSCoV‐2 and human coronaviruses reveal host factors potentially affecting pathogenesis

Z Chen, C Wang, X Feng, L Nie, M Tang… - The EMBO …, 2021 - embopress.org
… Overview of the interactome analysis between host and SARS-CoV-2 To comprehensively
illustrate the host and SARS-CoV-2 protein–protein interaction network, we performed an …

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

HH Hoffmann, FJ Sánchez-Rivera, WM Schneider… - Cell host & …, 2021 - cell.com
… To identify host factors required for infection by SARS-CoV-2 and … SARS-CoV-2 protein
interactome. We leveraged the compact nature of this library to systematically screen SARS-CoV-…