Understanding the HPV integration and its progression to cervical cancer

MA Oyervides-Muñoz, AA Pérez-Maya… - Infection, Genetics and …, 2018 - Elsevier
… by HPV, recent findings on the process of viral integration into … HPV integration occurs. To
understand how these new findings of HPV integration affect the progression of cervical cancer

Non-random integration of the HPV genome in cervical cancer

M Schmitz, C Driesch, L Jansen, IB Runnebaum… - PloS one, 2012 - journals.plos.org
… Light blue arrows: genes affected by HPV integration; red arrows: HPV fusion transcripts
described in this work; grey arrows: HPV fusion transcripts described by Kraus et al. 2008; …

The role of viral integration in the development of cervical cancer

T Yu, MJ Ferber, TH Cheung, TKH Chung… - Cancer genetics and …, 2005 - Elsevier
… where the sites of HPV integration in cervical tumors are nonrandom and where genes at
or near the sites of integration could play a role in the eventual cervical cancers that develop. …

Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism

Z Hu, D Zhu, W Wang, W Li, W Jia, X Zeng, W Ding… - Nature …, 2015 - nature.com
… (HPV) integration is a key genetic event in cervical … viral integration detection, we identified
3,667 HPV integration breakpoints in 26 cervical intraepithelial neoplasias, 104 cervical

[HTML][HTML] Integrating HPV vaccination programs with enhanced cervical cancer screening and treatment, a systematic review

C Wirtz, Y Mohamed, D Engel, A Sidibe, M Holloway… - Vaccine, 2022 - Elsevier
… to integrate HPV vaccination with cervical cancerintegration of HPV vaccination with cervical
cancer screening has been implemented in LMICs, determine whether and how integration

Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site

M Kamal, S Lameiras, M Deloger, A Morel… - … journal of cancer, 2021 - nature.com
… This is to our knowledge the first study assessing the prognostic value of HPV integration
in a prospectively annotated CC cohort, which detects a hotspot of HPV integration at …

The precision prevention and therapy of HPV‐related cervical cancer: new concepts and clinical implications

Z Hu, D Ma - Cancer medicine, 2018 - Wiley Online Library
… (HPV) has been identified as a major factor that leads to cervical cancer, although HPV
infection … Our groups also analyzed HPV integration breakpoints in 26 cervical intraepithelial …

Characteristic of HPV integration in the genome and transcriptome of cervical cancer tissues

W Li, Y Qi, X Cui, Q Huo, L Zhu, A Zhang… - BioMed research …, 2018 - Wiley Online Library
… gain insights into the HPV integration sites in DNA and RNA samples of cervical cancer. It
had provided … from the perspective of HPV integration in the HPV-associated cervical cancers. …

Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer

L Zhou, Q Qiu, Q Zhou, J Li, M Yu, K Li, L Xu… - Nature …, 2022 - nature.com
… genes in cervical cancer. Finally, we reveal the spatial relationship of HPV integration and its
… well as their functional consequences in cervical cancer. These findings provide insight into …

Multi-omics characterization of silent and productive HPV integration in cervical cancer

J Fan, Y Fu, W Peng, X Li, Y Shen, E Guo, F Lu, S Zhou… - Cell Genomics, 2023 - cell.com
HPV integration sites were nonrandomly distributed across both viral and host genomes,
suggesting that productive integration … tumors with productive HPV integration are associated …