HPV integration generates a cellular super-enhancer which functions as ecDNA to regulate genome-wide transcription

R Tian, Z Huang, L Li, J Yuan, Q Zhang… - Nucleic Acids …, 2023 - academic.oup.com
analysis on multi-omics data of six HPV-positive and three HPV-negative cell lines. Through
… Our results suggest that HPV integration generates cellular SEs that function as ecDNA to …

Multi-omics approach reveals influenza-A virus target genes associated genomic, clinical and immunological characteristics in cancers

J Wang, Y Liao, P Yang, W Ye, Y Liu, C Xiao, W Liao… - 2023 - researchsquare.com
… By mining data from multi-omics analysis, we have fully and systematically described IATGs
in many samples from thirtythree kinds of cancer types. Our ndings not only highlight the …

[HTML][HTML] Multi-omics analysis of LAMB3 as a potential immunological and biomarker in pan-cancer

Y Wang, G Li, ZY Wang, W Wang, X Wang… - Frontiers in Molecular …, 2023 - frontiersin.org
… The ggplot2 package was used for visualization analysis with a threshold of |log2 fold-…
statistical analysis with the cluster Profiler package for GO and KEGG enrichment analysis of DEGs…

[HTML][HTML] Three-dimensional chromatin analysis reveals Sp1 as a mediator to program and reprogram HPV-host epigenetic architecture in cervical cancer

C Cao, Q Xu, Z Zhu, M Xu, Y Wei, S Lin, S Cheng… - Cancer Letters, 2024 - Elsevier
… the HPV-host interactions. In addition, multi-omics analyses were performed to characterize
the key mediator of specificity protein 1 (Sp1) between HPV-host interactions. We found that …

Insights into tumor microenvironment and HPV integrations in cervical cancer pathogenesis revealed by single-cell transcriptome data

F Peng, X Zeng, Z Wang, Y Sha, RKK Leung, KCC LAI… - 2024 - researchsquare.com
… In this study, we focused on examining cellular heterogeneity and HPV infection/integration
and HPV integration analysis for 93,589 cells from 20 patients. This analysis revealed the …

[HTML][HTML] HPV DNA Integration at Actionable Cancer-Related Genes Loci in HPV-Associated Carcinomas

X Sastre-Garau, L Estrada-Virrueta, F Radvanyi - Cancers, 2024 - mdpi.com
… For the analysis, we kept only protein-coding genes with HPV insertions that were present
on Gencode, removing 64 genes that were not found. Certain gene names were changed to …

[HTML][HTML] Integrative models of histopathological image features and omics data predict survival in head and neck squamous cell carcinoma

H Zeng, L Chen, Y Huang, Y Luo, X Ma - Frontiers in Cell and …, 2020 - frontiersin.org
… Decision curve analysis also revealed a better net benefit of multi-omics model. … that
identification of HPV status was within the ability of histopathological images analysis, which needs …

[HTML][HTML] Multi-omics characterization of esophageal squamous cell carcinoma identifies molecular subtypes and therapeutic targets

D Zhao, Y Guo, H Wei, X Jia, Y Zhi, G He, W Nie… - JCI insight, 2024 - ncbi.nlm.nih.gov
… In summary, the multi-omics integrative analysis represents a valuable and potent tool that
offers a complementary and comprehensive understanding of ESCC, thereby providing an …

[HTML][HTML] A multi-omics approach based on 1H-NMR metabonomics combined with target protein analysis to reveal the mechanism of RIAISs on cervical carcinoma …

C Yanlan, A Jielili, J Wang, H Tang, Z Liu… - Aging (Albany NY …, 2023 - ncbi.nlm.nih.gov
… In this paper, basing on 1 H-NMR metabonomic and bioinformatics analysis, an integrated
multi-omics analysis including metabonomics and bioinformatics was performed. We propose …

The benefits of smoking cessation on survival in cancer patients by integrative analysis of multiomics data

S Yang, T Liu, G Liang - Molecular oncology, 2020 - Wiley Online Library
… risk compared with former smokers using multivariate Cox regression analysis [[9]]. Another
study … were not considered, including human papillomavirus (HPV) status associated with the …