[HTML][HTML] Transcriptionally active regions are the preferred targets for chromosomal HPV integration in cervical carcinogenesis

IK Christiansen, GK Sandve, M Schmitz, M Dürst… - PloS one, 2015 - journals.plos.org
… We find that integration sites coincide with DNA that is transcriptionally active in mucosal …
strongly implying the importance of transcriptionally active regions in the process of HPV

Genomic characterization of viral integration sites in HPV‐related cancers

C Bodelon, ME Untereiner, MJ Machiela… - … journal of cancer, 2016 - Wiley Online Library
… Overall, integration sites were more likely to be in gene regions than expected by chance (p
… to CpG regions, fragile sites, transcriptionally active regions and enhancers. Few integration

[HTML][HTML] Recurrent integration of human papillomavirus genomes at transcriptional regulatory hubs

A Warburton, TE Markowitz, JP Katz, JM Pipas… - NPJ Genomic …, 2021 - nature.com
HPV integration is also enriched at transcriptionally active … association among HPV integration
loci, common fragile sites, … whether insertion of HPV genomes adjacent to active cellular …

[HTML][HTML] Regulation of HPV transcription

AL Ribeiro, AS Caodaglio, L Sichero - Clinics, 2018 - SciELO Brasil
… Systematic review of genomic integration sites of human papillomavirus genomes in epithelial
… -6, a variant of the B1 sublineage was ten times more transcriptionally active than was a …

[HTML][HTML] Non-random integration of the HPV genome in cervical cancer

M Schmitz, C Driesch, L Jansen, IB Runnebaum… - PloS one, 2012 - journals.plos.org
… number of transcriptionally active HPV integration sites it has become evident that integration
is not an entirely random event but also involves preferred chromosomal sites. In individual …

[HTML][HTML] Transcriptional regulation of the papillomavirus oncogenes by cellular and viral transcription factors in cervical carcinoma

F Thierry - Virology, 2009 - Elsevier
… is integrated containing the regulatory region or “… HPV transcription, the keratinocyte specificity
is not yet fully understood. Indeed many transcription factors involved in HPV transcription

[HTML][HTML] The role of integration in oncogenic progression of HPV-associated cancers

AA McBride, A Warburton - PLoS pathogens, 2017 - journals.plos.org
transcriptionally active [9]. Continued expression of the E1 and E2 replication proteins from
HPV integration sites are those responsible for HPV cervical cancers. In these sites, the E6 …

Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma

AC Jung, J Briolat, R Millon… - … journal of cancer, 2010 - Wiley Online Library
transcriptionally active HPV and HPV-negative tumors. The loss of the chromosomal region
16q was found to be a major genetic event in HPVintegration or the physical state of the HPV

Transcriptional control of human papillomavirus (HPV) oncogene expression: composition of the HPV type 18 upstream regulatory region

K Butz, F Hoppe-Seyler - Journal of virology, 1993 - Am Soc Microbiol
… the transcriptionalregion indicates that its transcriptional activity is largely generated
by functional synergism between a centrally located AP1 module and thus far undetected cis-active

Dysregulation of host cellular genes targeted by human papillomavirus (HPV) integration contributes to HPV‐related cervical carcinogenesis

R Zhang, C Shen, L Zhao, J Wang… - … Journal of Cancer, 2016 - Wiley Online Library
… that transcriptional active region of chromatins were more accessible for HPV integration. …
were prone to occur into transcriptionally active regions of the cellular genome. The …