… The animals first underwent a PET examination of the 2-fluoro-2-deoxy-D-glucose (FDG)
transport and phosphorylation [17]. Immediately after the PET examination, the animals were …

… the herpes simplex virus thymidine kinase (HSVtk) gene, we were able to show that 2-fluoro-2-deoxyglucose
(FDG) uptake … in FDG uptake was mainly due to an increase in the transport …

… .transfer of the gene encoding the herpes simplex virus thymidine kinase (HSVtk) into tumor
cells confers sensitivity towards antiviral agents as acyclovir and ganciclovir (GCV) to these …

… transfer of the herpes simplex virus thymidine kinase (HSV-tk) … a retroviral vector containing
the HSV-tk gene, different clones … Uptake measurements were performed up to 48 hr in a TK-…

… of the thymidine (Thd) kinase (TK) of herpes simplex virus type 1 (HSV-1) on the intracellular
uptake … To compare the differences between the TK-positive (TK + ) and TK-deficient strains, …

Thymidine kinase from HSV-1 (HSV-1 TK) is a key enzyme in the metabolic activation of
antiviral nucleosides. High affinity of such compounds for the enzyme is required for efficient …

… (I) The HSV-1 TK gene coding for thymidine kinase is … The expression of HSV-1 thymidine
kinase and cellular kinases … by HSV-TK after they are actively transported into HSV-TK …

… We demonstrated that this newly identified NLS sequence was both necessary for specific
nuclear localization of HSV-1 TK and sufficient to transport VZV TK (which we found localized …

… a 3.4 kb fragment which contains the thymidine kinase gene and which alone is … herpes
simplex virus thymidine kinase gene is an ideal genetic element for studies on gene transfer…

… The initial target of these drugs is nearly in all cases the viral thymidine kinase (TK). This
enzyme is part of the thymine salvage pathway, catalyzing the transfer of the y-phosphate from …