… can explain HTLV-1 cell tropism. It also remains to be more definitively proven that these
molecules are sufficient to permit HTLV-1 entry into completely HTLV-1-resistant cells. …

… 1 binds HTLV-1 SU and is required for efficient HTLV-1 entry. The same study also showed
that NRP-1, GLUT1 and the HTLV-1 … The role of the third player of HTLV-1 entry, HSPGs, was …

… role in the binding and entry of HTLV-1 into CD4 + T cells (19). … HTLV-1 SU and HTLV-1
virions and the entry of HTLV-1 virions … Although HTLV-1 and HTLV-2 Env can facilitate entry into …

… proposed: (1) polarized budding of HTLV-1 into synaptic clefts; … Cell-to-cell transmission of
HTLV-1 requires a coordinated … of HTLV-1 transmission with a focus on the HTLV-1-encoded …

… human T cell lymphotropic virus-type 1 (HTLV-I), a retrovirus distantly related to HIV-1, cell-to-cell
… (1) report their direct visualization of HTLV-I-infected human T cells in the act of forming …

… Efficient entry of HTLV-1 has been shown to involve three distinct molecules: heparan …
HTLV-2 binding and entry also involves NRP-1 and GLUT1, but differs from HTLV-1 in that it does …

… of HTLV-1 entry and that HTLV-1 mimics VEGF 165 to recruit HSPGs and NRP-1: (1) the NRP-1
b domain is required for HTLV-1 … -1 complexes is enhanced by HSPGs; and (4) the HTLV …

… to draw the following sequence of events leading to HTLV-1 Env-mediated entry: (i) Attachment
and increased mobilization of HTLV particles at the target cell surface via attachment to …

… is highly conserved among HTLV- 1 strain and can block the HTLV-1 entry into DCs … HTLV-
1 SU is pivotal in the direct binding of VEGF-165 to the NRP-1; thus, indicating that the NRP-1 …

… , are thought to be important for the interaction between the HTLV-1 envelope and the cell
membrane, and for entry of the virus to cells. It has been suggested that the virus may first …