… Furthermore, while transcripts of the spliced HBZ gene … of HTLV-1 viral genes in ATL
patients was deemed to be undetectable. Therefore, the HBZ gene is recognized as the first gene …

… Thus, the HBZ gene is believed to be essential for leukemogenesis. In this review, we …
understanding of HTLV-1 and focus on the roles of HBZ in HTLV-1 oncogenesis. FIGURE 1 …

… The HTLV-1 bZIP factor (HBZ) gene was discovered in 2002 … Thus HBZ has become a novel
hotspot of HTLV-1 research. … fact that the HBZ gene is the only HTLV-1 gene present in all …

… spliced HBZ gene was transcribed in all the HTLV-1 infected … between HTLV-1 HBZ mRNA
load and HTLV-1 proviral load, … /TSP patients, indicating that HTLV-1 HBZ mRNA load may be …

… In this review, we summarize what is known about HBZ and discuss its significance in
pathogenesis by HTLV-1. Transcriptional control of the hbz gene Expression of the hbz gene is …

… HTLV-1-mediated oncogenesis [12]. Sp1 binding sites in the 3' LTR of HTLV-1 have been
demonstrated to be critical for HBZ … of housekeeping genes, the transcription of the HBZ gene …

… cell proliferation, genetic instability, and miRNA dysregulation. Meanwhile, HBZ is expressed
… Here, we show that an HBZ–miRNA axis promotes cell proliferation and genetic instability, …

… the effect of the HBZ gene in T cells, we co-transfected Jurkat T cells with the pGL3-378
reporter construct with either JunD or both JunD and HBZ (Fig 1C). It was observed that HBZ, in …

… not found in the HBZ gene in both ATL cases and HTLV-1 carriers, suggesting that HBZ
expression is … Since viral genes other than the HBZ gene are transcribed from the 5′LTR that is …

… This study aimed to assess the role of the TAX and HBZ genes and HTLV-1 proviral load (…
The HTLV-1 TAX and HBZ genes encode highly motivated proteins that disrupt the cell cycle …