Activation of NF-κB by HTLV-I and implications for cell transformation
SC Sun, S Yamaoka - Oncogene, 2005 - nature.com
… However, HTLV-I induces persistent activation of NF-κB, … HTLV-I transforming protein Tax
functions as an intracellular stimulator of IκB kinase (IKK), a cellular kinase mediating NF-κB …
functions as an intracellular stimulator of IκB kinase (IKK), a cellular kinase mediating NF-κB …
NF‐κB signaling mechanisms in HTLV‐1‐induced adult T‐cell leukemia/lymphoma
… Tax is a potent activator of NF-κB, a key signaling pathway that is essential for the survival
and proliferation of HTLV-1-infected T cells. However, constitutive NF-κB activation by Tax …
and proliferation of HTLV-1-infected T cells. However, constitutive NF-κB activation by Tax …
Mechanisms of NF-κB Activation by the HTLV Type 1 Tax Protein
… of the NF-kB pathway by Tax is believed to be one of the major events involved in HTLV-1-…
This review summarizes data exploring the role of Tax in activating the NF-kB pathway and …
This review summarizes data exploring the role of Tax in activating the NF-kB pathway and …
HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor
K Leung, GJ Nabel - Nature, 1988 - nature.com
… , HTLV-I and HIV-1 use this class of transcription factors in different ways. Our data suggest
that an NF-k B-like factor is a target of HTLV-… In the case of T cells infected with HIV, NF-k B is …
that an NF-k B-like factor is a target of HTLV-… In the case of T cells infected with HIV, NF-k B is …
Persistent activation of NF-κB by the tax transforming protein of HTLV-1: hijacking cellular IκB kinases
SC Sun, DW Ballard - Oncogene, 1999 - nature.com
… transduction, NF-κB is constitutively deployed in T-cells transformed by the type 1 human
T-cell leukemia virus (HTLV-1). This viral/host interaction is mediated by the HTLV-1-encoded …
T-cell leukemia virus (HTLV-1). This viral/host interaction is mediated by the HTLV-1-encoded …
[PDF][PDF] Mechanisms of HTLV-1 transformation
K Kehn, R Berro, C de la Fuente, K Strouss… - Front …, 2004 - researchgate.net
… model to explain the constitutive NF-kappaB activity observed in HTLV-1 infected cells,
studies continue to elucidate additional steps within the NFkappaB signaling pathway that Tax …
studies continue to elucidate additional steps within the NFkappaB signaling pathway that Tax …
Dynamic roles for NF‐κB in HTLV‐I and HIV‐1 retroviral pathogenesis
JK Chan, WC Greene - Immunological reviews, 2012 - Wiley Online Library
… , HTLV-I and HIV-1 (1, 2). We discuss how HTLV-I and HIV-1 manipulate NF-κB by … , and
how understanding the dynamic interplay between NF-κB and these retroviruses might provide …
how understanding the dynamic interplay between NF-κB and these retroviruses might provide …
Molecular mechanisms of HTLV-1 infection and pathogenesis
J Yasunaga, M Matsuoka - International journal of hematology, 2011 - Springer
… 4.1 Activation of the NF-κB pathway NF-κB is a major survival pathway engaged by HTLV-1.
Tax was shown to bind IKKγ, and to activate both the canonical and non-canonical …
Tax was shown to bind IKKγ, and to activate both the canonical and non-canonical …
Activated AKT regulates NF-κB activation, p53 inhibition and cell survival in HTLV-1-transformed cells
SJ Jeong, CA Pise-Masison, MF Radonovich, HU Park… - Oncogene, 2005 - nature.com
… Finally, AKT prosurvival function in HTLV-1-transformed cells is linked to expression of Bcl-…
of prosurvival pathways in HTLV-1-transformed cells, possibly through NF-κB activation and …
of prosurvival pathways in HTLV-1-transformed cells, possibly through NF-κB activation and …
[HTML][HTML] Regulation of NF-κB by the HTLV-1 Tax protein
… The Tax protein encoded by the human T-cell leukemia virus type 1 (HTLV-1) activates viral
… NF-κB. The ability of Tax to activate the NF-κB pathway plays an essential role in HTLV-1-…
… NF-κB. The ability of Tax to activate the NF-κB pathway plays an essential role in HTLV-1-…
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