… However, HTLV-I induces persistent activation of NF-κB, … HTLV-I transforming protein Tax
functions as an intracellular stimulator of IκB kinase (IKK), a cellular kinase mediating NF-κB …

… Tax is a potent activator of NF-κB, a key signaling pathway that is essential for the survival
and proliferation of HTLV-1-infected T cells. However, constitutive NF-κB activation by Tax …

… of the NF-kB pathway by Tax is believed to be one of the major events involved in HTLV-1-…
This review summarizes data exploring the role of Tax in activating the NF-kB pathway and …

… , HTLV-I and HIV-1 use this class of transcription factors in different ways. Our data suggest
that an NF-k B-like factor is a target of HTLV-… In the case of T cells infected with HIV, NF-k B is …

… transduction, NF-κB is constitutively deployed in T-cells transformed by the type 1 human
T-cell leukemia virus (HTLV-1). This viral/host interaction is mediated by the HTLV-1-encoded …

… model to explain the constitutive NF-kappaB activity observed in HTLV-1 infected cells,
studies continue to elucidate additional steps within the NFkappaB signaling pathway that Tax …

… , HTLV-I and HIV-1 (1, 2). We discuss how HTLV-I and HIV-1 manipulate NF-κB by … , and
how understanding the dynamic interplay between NF-κB and these retroviruses might provide …

… 4.1 Activation of the NF-κB pathway NF-κB is a major survival pathway engaged by HTLV-1.
Tax was shown to bind IKKγ, and to activate both the canonical and non-canonical …

… Finally, AKT prosurvival function in HTLV-1-transformed cells is linked to expression of Bcl-…
of prosurvival pathways in HTLV-1-transformed cells, possibly through NF-κB activation and …

… The Tax protein encoded by the human T-cell leukemia virus type 1 (HTLV-1) activates viral
… NF-κB. The ability of Tax to activate the NF-κB pathway plays an essential role in HTLV-1-…