… in HTLV-1 pathogenesis and some of the lessons in immunology learnt from HTLV-1. …
importance of HBZ in maintaining HTLV-1 persistence, HTLV-1 would have evolved to minimise …

… persistent transcription of HTLV-1. But how much? More precisely: how important is persistent
HTLV-1 … efficacy of retroviral drugs or immunotherapy for HTLV-I–infected individuals? It …

Human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus to be discovered as a
causative agent of adult T-cell leukemia-lymphoma (ATL) and chronic inflammatory diseases. …

… Adult T-cell leukaemia (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1).
HTLV-1 has elaborated strategies to persist and replicate in the presence of a strong …

… In light of our overall theme of understanding HTLV-I persistence, in this section, we consider
the following conundrum: Why is HTLV-I not silent? Indeed, the expression of viral proteins …

… rarely occurs; HTLV-1 rather relies on clonal … HTLV-1 infection in vivo and eventually cause
the onset of ATLL. This review summarizes our current understanding of HTLV-1 persistence …

… We considered a simplified model of HTLV-1 persistence that does not describe individual
clone dynamics. If S(t) and N(t) are the number of clones and number of infected cells …

… found in infected patients and their potential impact on viral load, transmission and persistence.
Finally, we will compare the orf-I gene in HTLV-1 subtypes as well as related STLV-1. …

… that HTLV-1 uses to avoid immune detection, which results in lifelong persistent infection in
… underpin future developments in effective therapy for, and prevention of, HTLV-1 infection. …

… via clonal proliferation, resulting in the persistence and survival of the virus. The … HTLV-1
to modulate and subvert host immune responses which contributes to viral persistence …