Tissue-resident memory T cells populate the human brain

J Smolders, KM Heutinck, NL Fransen… - Nature …, 2018 - nature.com
… by tissue-resident memory T cells (T RM cells), which are adapted … human white matter-derived
brain CD8 + T cells can be subsetted into CD103 − CD69 + and CD103 + CD69 + T cells

Human memory T cells: generation, compartmentalization and homeostasis

DL Farber, NA Yudanin, NP Restifo - Nature Reviews Immunology, 2014 - nature.com
… current knowledge of human memory T cells. We describe … investigate how memory T cells
are organized in human tissue … of T cell subsets and their specificities within the human body

Resident memory T cells in human health and disease

RA Clark - Science translational medicine, 2015 - science.org
memory T cells, exploring how these cells contribute to healthy immune function and discussing
what is known about how these cells contribute to human … all T and B cells in the body, …

Regional and mucosal memory T cells

BS Sheridan, L Lefrançois - Nature immunology, 2011 - nature.com
… The human body is separated from the outside world by barrier surfaces that carry out many
… contain most the body's memory T cells. Other tissues, such as the brain, bone marrow and …

Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice

…, F van der Meer, N Page, B Klimek… - Science translational …, 2019 - science.org
brains imprinted a chronic inflammatory signature that consisted of brain-resident memory
T cells … In mouse and human brain, CCL5 + T RM were located predominantly to sites of …

The emerging role of resident memory T cells in protective immunity and inflammatory disease

CO Park, TS Kupper - Nature medicine, 2015 - nature.com
… of memory T cells: tissue-resident memory T cells, or T RM cells. Under physiological
conditions, T RM cells … Whether such T RM cells can form in human brain after viral infection is …

Tissue‐resident memory T cells

H Shin, A Iwasaki - Immunological reviews, 2013 - Wiley Online Library
… tissues in the body based on patterns of memory T-cell … CCR7+ memory T cells, termed central
memory T cells (T … , while CCR7 − memory T cells, named effector memory T cells (T EM ), …

Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory

A Okhrimenko, JR Grün, K Westendorf… - Proceedings of the …, 2014 - National Acad Sciences
… This is a drastic reversal of the current concept that memory T cells recirculate throughout
the body to find their cognate antigen, presented to them by APCs in SLOs. If …

CXCR3 marks CD4+ memory T lymphocytes that are competent to migrate across a human brain microvascular endothelial cell layer

MK Callahan, KA Williams, P Kivisäkk, D Pearce… - Journal of …, 2004 - Elsevier
… Chemokines and their receptors may be implicated in leukocyte ingress into brain during …
+ memory T lymphocytes during diapedesis, we used an in vitro model of the blood–brain

Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions

…, MCJ Vincenten, EBM Remmerswaal, T Kuhlmann… - Brain, 2020 - academic.oup.com
… Here we provide an extensive analysis of the phenotypic profile and spatial localization of
human brain T cells in relation to the post-mortem pathology of advanced multiple sclerosis. …