… signaling properties and highlight the specificities of AKT kinases that have emerged from
the study of human cancer and animal models. While AKT kinases are an attractive target for …

… AKT/PKB (protein kinase B) kinases mediate signaling pathways downstream of activated
tyrosine kinases and phosphatidylinositol 3-kinase. AKT kinases regulate diverse cellular …

… , which is also known as protein kinase B (PKB; reviewed in Refs 22,23). Our focus … AKT
function, with an emphasis on its links to human cancer. AKT encodes a serine/threonine kinase …

… Abstract: Akt (protein kinase B) is a serine/threonine kinase which is a central regulator of
widely divergent cellular processes including proliferation, differentiation, migration, survival …

… AKT kinases emerging from recent studies of human cancers and rodent models, as well as
the status of current efforts to specifically target individual AKT family … While AKT kinases are …

… PIP3 in turn contributes to the recruitment and activation of a wide range of downstream
targets, including the serine-threonine protein kinase Akt (also known as protein kinase B). The …

… Akt expression level or activity is a causative factor for the onset or progression of a variety of
human cancers … with and recruits both Akt and phosphoinositide-dependent kinase 1 (PDK1…

… Downstream activation of the AKT kinase is regarded as the dominant tumor-promoting …
shows that AKT signaling is markedly diminished in many cancer cell lines and human breast …

… This is largely due to that PI3K/Akt/mTOR signaling is … inhibitors targeting major kinase
components of the PI3K/Akt/mTOR … Targeting a single kinase component within this signaling …

… Akt is a serine/threonine-specific protein kinase, which plays a key role in multiple cellular
processes including apoptosis and cell proliferation. Phosphorylation and activation of …