Targeting GPX4 in human cancer: Implications of ferroptosis induction for tackling cancer resilience

J Lee, JL Roh - Cancer Letters, 2023 - Elsevier
human cancer, which leads to implications of ferroptosis induction for tackling cancer resilience.
… targeting the GPX4 pathway in human cancer, which leads to implications of ferroptosis

Recent progress in ferroptosis inducers for cancer therapy

C Liang, X Zhang, M Yang, X Dong - Advanced materials, 2019 - Wiley Online Library
… drugs based on ferroptosis induction. Recent advances of ferroptosis-inducing agents at
the … All of these highlight the promising role of ferroptosis induction in cancer treatment. …

Dietary lipids induce ferroptosis in caenorhabditiselegans and human cancer cells

MA Perez, L Magtanong, SJ Dixon, JL Watts - Developmental cell, 2020 - cell.com
… PUFAs are sufficient to induce ferroptosis alone is, however, unclear. To investigate whether
exogenous DGLA alone could induce ferroptosis, we treated ferroptosis-sensitive HT-1080 …

[HTML][HTML] Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer

F Pu, F Chen, Z Zhang, D Shi, B Zhong, X Lv… - Genes & …, 2022 - Elsevier
… of lipid peroxidation, thus preventing the production of ROS and negatively regulating
erastin-induced ferroptosis in human cervical cancer cells, osteosarcoma cells, and prostate …

[HTML][HTML] Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite

K Subburayan, F Thayyullathil, S Pallichankandy… - Translational …, 2020 - Elsevier
… , we report that SS induces ferroptosis in a number of human cancer cells (MCF-7… -induced
ferroptosis. Additionally, this study provides a molecular link between ROS and the ferroptosis

Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer

A Ghoochani, EC Hsu, M Aslan, MA Rice, HM Nguyen… - Cancer research, 2021 - AACR
cancer cells are vulnerable to ferroptosis induction, and FINs may represent a new class of
therapeutic agents for advanced prostate cancercancer is sensitive to ferroptosis induction, …

Unleashing ferroptosis in human cancers: targeting ferroptosis suppressor protein 1 for overcoming therapy resistance

J Lee, JL Roh - Antioxidants, 2023 - mdpi.com
… and its modulation, as well as exploring the potential of targeting FSP1 for ferroptosis
induction in cancer therapy, is crucial. This review aims to provide a comprehensive overview of …

Molecular mechanisms of ferroptosis and its role in cancer therapy

T Xu, W Ding, X Ji, X Ao, Y Liu, W Yu… - Journal of cellular and …, 2019 - Wiley Online Library
… stress induced by ferroptotic reagents promotes ferroptosis … Lysosome is also involved in
ferroptosis induction through … ferroptosis induction in several special types of cancer cells. …

Induction and application of ferroptosis in cancer therapy

Q Nie, Y Hu, X Yu, X Li, X Fang - Cancer Cell International, 2022 - Springer
… , ferroptosis has been shown to induce tumor cell death, providing new ideas for tumor treatment.
In this article, we summarize the latest advances in ferroptosis-induced … of ferroptosis in …

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

B Chu, N Kon, D Chen, T Li, T Liu, L Jiang, S Song… - Nature cell …, 2019 - nature.com
human cancer cells, Nutlin-mediated p53 activation induces … , ROS stress-induced ferroptosis
upon combined treatment with … -mediated ferroptosis is deregulated in human cancers, we …