… the basic causes of human cancer. Through an understanding … cancer cells select mutations
having two basic functions: … or mutations which inactivate gene function in the case of genes …

… Heat shock protein-70 (Hsp70) is another of the HRG-inducible gene products found in
human breast cancer cells; since Hsp70 acts as a molecular chaperone with cell survival function…

… Mitochondrial copy number varies greatly within and across cancers and correlates with
clinical variables. Co-expression analysis highlights the function of mitochondrial genes in …

… of review on the function and clinical roles of miR-126 in human cancers. A review of the
literature, however, shows that miR-126 has been investigated in many human cancers. In the …

… Indeed, while loss of function has been implicated in … , gain of function leads to
immunosuppression and tumor metastasis [6, 9, 19, 20]. Thus, TGFβ plays a dual role in human …

… of cancer, further highlighting its regulatory importance [112]. In conclusion, lncRNAs
function as epigenetic regulators of gene expression through a variety of different mechanisms. …

… genes have contributed substantially to our understanding of the somatic mutations present
in sporadic cancers, as well as the function of cell signaling pathways. Studies of the APC …

… its function as a transcriptional regulator and its role as a mediator of development, normal
physiology, and pathology of many diseases, including cancers. … biology of human cancers. …

… as his discovery set the foundation of our current understanding of experimental and human
cancer biology. … The molecular function of E6 and E7 provided one of the first evidences that …

… Additional support for the function of miRNAs in human cancers has come from transgenic
and knockout mouse models, which have been important for understanding the tumorigenic …