Assessment of the inhibitory effects of pyrethroids against human carboxylesterases

W Lei, DD Wang, TY Dou, J Hou, L Feng, H Yin… - Toxicology and Applied …, 2017 - Elsevier
… that widely used in many countries, while humans may be exposed to these toxins by … the
inhibitory effects of six commonly used pyrethroids against two major human carboxylesterases

Different inhibitory effects in rat and human carboxylesterases

S Takahashi, M Katoh, T Saitoh, M Nakajima… - Drug metabolism and …, 2009 - ASPET
… However, the profile of the inhibitory effects of carboxylesteraseinhibitory effects of 15 drugs
and 1 compound on CES activity using liver and jejunum microsomes and cytosol in human

[HTML][HTML] Human carboxylesterases: a comprehensive review

D Wang, L Zou, Q Jin, J Hou, G Ge, L Yang - Acta Pharmaceutica Sinica B, 2018 - Elsevier
inhibitory effects toward CES1 or CES2; these agents do not exhibit inhibitory effects on
human … Benzene sulfonamides usually displayed potent inhibitory effects against CES2 and …

In vitro evaluation of inhibitory effects of antidiabetic and antihyperlipidemic drugs on human carboxylesterase activities

T Fukami, S Takahashi, N Nakagawa, T Maruichi… - Drug metabolism and …, 2010 - ASPET
… In the present study, we examined the inhibitory effects of various antidiabetic or
antihyperlipidemic drugs on CES1A1 enzyme activity. In addition, the inhibitory effect on CES2 …

Evaluation of the inhibitory effects of antihypertensive drugs on human carboxylesterase in vitro

X Yanjiao, Z Chengliang, L Xiping, W Tao… - Drug Metabolism and …, 2013 - Elsevier
… In the present study, the inhibitory effects of 17 antihypertensive … and human liver microsomes
(HLM) were intensely inhibited by … However, other drugs did not exert strong inhibition. The …

Recent progress in the discovery of natural inhibitors against human carboxylesterases

DD Wang, LW Zou, Q Jin, J Hou, GB Ge, L Yang - Fitoterapia, 2017 - Elsevier
… of two major human carboxylesterases (hCE1 and hCE2) have been reported, part of them
are used as highly selective and practical tools to investigate the inhibitory effects of natural …

Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2

YG Li, J Hou, SY Li, X Lv, J Ning, P Wang, ZM Liu… - Fitoterapia, 2015 - Elsevier
… the inhibitory effects of the crude ethanol extract from FP on human carboxylesterase 2 (hCE2), …
Our results demonstrated that the ethanol extract of FP displayed potent inhibitory effects

Inhibitory effects of phthalate esters (PAEs) and phthalate monoesters towards human carboxylesterases (CESs)

J Gong, X Yi, J Liang, Z Liu, Z Du - Toxicology and Applied Pharmacology, 2024 - Elsevier
… is to investigate the inhibitory effect of PAEs and phthalate monoesters on the activity of
human CES1 and CES2. In order to gather comprehensive information, the inhibition of 14 kinds …

Evaluation of the inhibitory effects of antigout drugs on human carboxylesterases in vitro

J Liang, X Yi, J Gong, Z Du - Toxicology in Vitro, 2024 - Elsevier
… was to investigate the inhibitory effect of antigout drugs (allopurinol, febuxostat, topiroxostat,
benzbromarone, lesinurad and probenecid) on human CES1 and CES2. Inhibition kinetics …

Investigation of the inhibitory effect of protostanes on human carboxylesterase 2 and their interaction: Inhibition kinetics and molecular stimulations

X Lv, R Bai, JK Yan, HL Huang, XK Huo… - International Journal of …, 2021 - Elsevier
… The present study aimed to investigate the inhibitory effects of the major constituents of A.
orientale on human CES 2, as well as to characterize the inhibition constant (K i ) and the …