[HTML][HTML] Salt increases monocyte CCR2 expression and inflammatory responses in humans

EFE Wenstedt, SGS Verberk, J Kroon, AE Neele… - JCI insight, 2019 - ncbi.nlm.nih.gov
… randomized crossover trial in which 11 healthy human subjects adhered to a 2-… monocyte
expression of CCR2, a chemokine receptor that mediates monocyte infiltration in inflammatory

Selective inhibition of expression of the chemokine receptor CCR2 in human monocytes by IFN-γ

G Penton-Rol, N Polentarutti, W Luini… - The Journal of …, 1998 - journals.aai.org
… of the MCP receptor CCR2 in monocytes. These … monocytes. The inhibition of MCP-1R
expression may serve as a means of retaining mononuclear phagocytes at sites of inflammation

Monocyte subtypes and the CCR2 chemokine receptor in cardiovascular disease

CN França, MCO Izar, MNS Hortêncio… - Clinical …, 2017 - portlandpress.com
… number of classical monocytes (which express CCR2) at the sites of inflammation, without
… In another study [68], the endogenous murine CCR2 gene was replaced with human CCR2 (…

Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis

DE Sanford, BA Belt, RZ Panni, A Mayer… - Clinical cancer …, 2013 - AACR
… CCL2, and immunosuppressive CCR2 + macrophages infiltrate … In mice, CCR2 blockade
depletes inflammatory monocytes and … to the peripheral blood in human pancreatic cancer (7). …

[HTML][HTML] … -inflammatory CD11chighCCR2+ CX3CR1+ macrophages, but not their tolerogenic CD11c− CCR2− CX3CR1− counterparts, are expanded in inflammatory …

D Bernardo, AC Marin, S Fernández-Tomé… - Mucosal …, 2018 - Elsevier
… Moreover, monocyte recruitment was CCR2 dependent as … all cases if CCR2 had been
blocked on the monocytes prior to … human colonic mucosa attract CD14 + monocytes via CCR2, …

[PDF][PDF] Expression of CCR2 on monocytes and macrophages in chronically inflamed skin in atopic dermatitis and psoriasis.

C Vestergaard, H Just… - Acta dermato …, 2004 - researchgate.net
… of MCP-1 in the inflammatory skin diseases AD and psoriasis. … the chemokine receptor CCR2
in human monocytes by IFN-… Human monocytes express CD163, which is upregulated by …

CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis

H Raghu, CM Lepus, Q Wang, HH Wong… - Annals of the …, 2017 - ard.bmj.com
… Importantly, we show that as in mouse OA, in human OA CCR2 ligands such as CCL2
and CCL8, but not CCR5 ligands such as CCL5, are preferentially elevated. Finally, we …

Role of CCR2 in inflammatory conditions of the central nervous system

HX Chu, TV Arumugam, M Gelderblom… - Journal of Cerebral …, 2014 - journals.sagepub.com
inflammatorymonocytes, as a large number of Ly6C hi monocytes are recruited to inflamed
tissue in a CCR2… , which acts on both human and murine CCR2. In a mouse model of EAE, …

Loss of CCR2 expression and functional response to monocyte chemotactic protein (MCP-1) during the differentiation of human monocytes: role of secreted MCP-1 in …

L Fantuzzi, P Borghi, V Ciolli, G Pavlakis… - Blood, The Journal …, 1999 - ashpublications.org
… the levels of CCR2 mRNA in monocytes/… monocytes express high levels of CCR2 receptors
that are activated by chemoattractant stimuli released at inflammatory sites; (2) monocytes

Chemokine receptor CCR2 expression and monocyte chemoattractant protein-1–mediated chemotaxis in human monocytes: a regulatory role for plasma LDL

KH Han, RK Tangirala, SR Green… - … , and vascular biology, 1998 - Am Heart Assoc
… being the predominant form on human monocytes, are highly … that monocyte CCR2
expression is affected by inflammatory … control monocyte responses through modulation of CCR2