… (A) TNF-α release by human CCR2+ monocytes from two different donors treated with soluble
SP-D in the presence of either IgG1 or anti-OSCAR blocking mAbs, 11.20.08 or 11.20.25. (…

… a human lung disease caused by autosomal recessive, complete deficiency of the monocyte
chemokine receptor CC motif chemokine receptor 2 (CCR2). Nine … The CCR2 variants are …

… We first established a murine model of cumulative ICD induced by repeated exposure to
surfactant SDS, one of the most common causative agents of human ICD. Ear skin of wild-type (…

… + pool results in disease modifying effects on SP-C I73T induced injury, we opted to utilize
a knock out model directly targeting CCR2 monocytes (SP-C I73T CCR2 KO ). We confirmed …

… human OSCAR Fcfusion protein (OSCAR-Fc) to recombinant forms of SP-D, in addition to
C1q and MBL proteins (… Surfactant protein D influences surfactant ultrastructure and uptake by …

… Using this purified protein, we found that human FROUNT is able to bind to CCR2 without
any additional components. We also determined that human FROUNT exists in homo-…

… We first established a murine model of cumulative ICD induced by repeated exposure to
surfactant SDS, one of the most common causative agents of human ICD. Ear skin of wild-type (…

The attraction of leukocytes from circulation to inflamed lungs depends on the activation of
both the leukocytes and the resident cells within the lung. In this study we determined gene …

… characterized by abnormal surfactant accumulation within … proteins such as MCP-2 and
MCP-3, which share the CCR2 … In human PAP, the potential contribution of autoimmunity to …

… Expression and localization of lung surfactant protein A in human tissues. Am J Respir Cell
… Surfactant proteins A and D enhance the phagocytosis of Chlamydia into THP-1 cells. Am J …