… , TNF-α, and IL-1β in inhibiting CCR2 expression. IFN-γ-treated monocytes showed a shorter
half-life of CCR2 … IFN-γ selectively inhibited the expression of CCR2 in human monocytes. …

… The study was designed as a phase IIa clinical trial with a human CCR2 blocking antibody
(… Expression of interleukin-1β (IL-1β), tumor necrosis factor α (TNFα), and CCR2 is in …

… Interestingly, IFN-γ also selectively inhibits the CCR2 expression on human monocytes [28].
It seems that differences in IFN-γ regulation of CCL2 may result from … tumor necrosis factor α …

… This article reviews patents of synthetic and biological products that are claimed to play a
role in several human diseases because of their capability to block CCR2 signalling. …

… In another study [68], the endogenous murine CCR2 gene was replaced with human CCR2
(huCCR2ki) and the authors analyzed the effect of the CCR2 antagonist GSK1344386B on …

… the CCL2/CCR2 system in patients with active RA may be sensitive to anti-TNF-α therapy
and … Production of monocyte chemotactic protein-1 in human type B synoviocytes. Synergistic …

… /or do not correlate with CCR2 protein levels, and CCR2 expression is … CCR2 mRNA
expression in human and simian astrocytes is enhanced by inflammatory cytokines such as TNFα …

… Mono Mac 6 cells and adherent monocytes were treated with the indicated concentrations
of human recombinant TNF-α (kindly provided by BASF), oxLDL (a kind gift of Dr N. Hrboticky) …

… relationship between MSCs and human tumor development, lack … CCR2, thus exerting a
much stronger tumor promoting effect than BM-MSCs. Importantly, BM-MSCs exposed to TNFα …

… T cells are important producers of TNF-α and CCR5 plays a … between TNF-α and CCR5
in activated human peripheral … chemokine receptor CCR2 in human monocytes by IFN-γ. …