… Even something apparently as trivial as the position of a gene within a chromosome can
greatly affect its behaviour. Heterochromatin (Chapter 7) consists of chromosomal segments …

… Genome Organization We next consider the relationship between our results and molecular
characterization of genome organization … ) is reflected in a chromosomal structure, the R …

… Genome-wide studies have indicated that the imprinted H19/Ig2 locus on human chromosome
11 physically interacts with regulatory elements on other chromosomes and that these …

… begin to yield a more coherent picture that integrates linear and three-dimensional (3D)
views of chromosome organization in relation to gene regulation and other nuclear functions. …

… positive by FISH had a corresponding chromosomal … human genome assembly, requiring
the development of specialized techniques to finish these exceptional regions of the genome. …

… is an invaluable aid to analysing the complex genomes of vertebrates, but tbe biochemical
… of genome organization tbat may play roles in chromosome banding. Chromosome banding …

… our previous knowledge of genome organization in a critical size range which encompasses
isochores, interphase chromatin domains and boundaries and chromosomal bands. A key …

… We studied the genome organization of human lung fibroblast (IMR90) and embryonic stem
… data and coarse-grained physical models of chromosomes. The models were specialised for …

… genomic organization of these sequences, with particular emphasis on the constituents of
individual chromosomes (3… , if not all, human chromosomes are characterized by distinct alpha …

… regions of the genome rather than functional classes of genes, we examined all of the genes
on human chromosomes 21 and 22. Among 144 known genes located on chromosome 21, …