The importance of inflammatory mechanisms in Alzheimer disease

EG McGeer, PL McGeer - Experimental gerontology, 1998 - Elsevier
… the neuronal death in Alzheimer disease and possibly … cortical metabolism with nootropics.
Such pharmacological approaches do not attempt to slow the very rapid destruction of cortical

[HTML][HTML] Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation: effects of Alzheimer disease and identification of lipoxidation targets

R Pamplona, E Dalfó, V Ayala, MJ Bellmunt… - Journal of Biological …, 2005 - ASBMB
… acid composition in brain samples from Alzheimer disease patients and agematched controls,
… formation in brain cortex by proteomic techniques. Alzheimer disease was associated with …

[HTML][HTML] Alzheimer disease models and human neuropathology: similarities and differences

C Duyckaerts, MC Potier, B Delatour - Acta neuropathologica, 2008 - Springer
… the cause(s) of Alzheimer disease. Numerous mouse transgenic lines … human APP transgenes
result in the deposition of Aβ peptide, similar but not identical to the Aβ peptide of human

Neuropathologic correlates of human cortical proteins in Alzheimer disease and related dementias

L Yu, PA Boyle, AP Wingo, J Yang, T Wang… - Neurology, 2022 - AAN Enterprises
… We previously reported human cortical proteins that are implicated in Alzheimer dementia. …
proteins for underlying disease mechanisms, we investigated cortical protein associations …

Pathology of the insular cortex in Alzheimer disease depends on cortical architecture

DJ Bonthius, A Solodkin… - … of Neuropathology & …, 2005 - academic.oup.com
… This study demonstrated that the insular cortex is a prominent target of Alzheimer disease.
In many cases of Alzheimer disease, the insula is heavily burdened with NFTs, NPs, and Alz-…

[HTML][HTML] A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research

PL De Jager, Y Ma, C McCabe, J Xu, BN Vardarajan… - Scientific data, 2018 - nature.com
We initiated the systematic profiling of the dorsolateral prefrontal cortex obtained from a
subset of autopsied individuals enrolled in the Religious Orders Study (ROS) or the Rush …

What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus

…, Alzheimer's Disease Neuroimaging Initiative - Progress in …, 2014 - Elsevier
… of undetected disease. We review recent research on changes of the cerebral cortex and …
We argue that prominent cortical reductions are evident in fronto-temporal regions in elderly …

Cortical plasticity in Alzheimer's disease in humans and rodents

F Battaglia, HY Wang, MF Ghilardi, E Gashi… - Biological …, 2007 - Elsevier
BACKGROUND: The aim of this study was to determine whether neocortical long-term
potentiation (LTP) is deficient in patients with Alzheimer’s disease (AD) and in amyloid precursor …

Oxidative stress in the progression of Alzheimer disease in the frontal cortex

MA Ansari, SW Scheff - Journal of Neuropathology & …, 2010 - academic.oup.com
… increasing in a disease-dependent fashion. These correlations implicate an involvement of
oxidative stress in Alzheimer disease-related synaptic loss. Alzheimer disease, Free radicals, …

Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease

M Morawski, S Schilling, M Kreuzberger… - … of Alzheimer's …, 2014 - content.iospress.com
… Brains of Alzheimer’s disease (AD) patients are characterized in part by the formation of …
Here, we addressed the role of QC in AD pathogenesis in human cortex. Two sets of human