The importance of inflammatory mechanisms in Alzheimer disease

EG McGeer, PL McGeer - Experimental gerontology, 1998 - Elsevier
… the neuronal death in Alzheimer disease and possibly … cortical metabolism with nootropics.
Such pharmacological approaches do not attempt to slow the very rapid destruction of cortical

[HTML][HTML] Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation: effects of Alzheimer disease and identification of lipoxidation targets

R Pamplona, E Dalfó, V Ayala, MJ Bellmunt… - Journal of Biological …, 2005 - ASBMB
… acid composition in brain samples from Alzheimer disease patients and agematched controls,
… formation in brain cortex by proteomic techniques. Alzheimer disease was associated with …

[HTML][HTML] Alzheimer disease models and human neuropathology: similarities and differences

C Duyckaerts, MC Potier, B Delatour - Acta neuropathologica, 2008 - Springer
… the cause(s) of Alzheimer disease. Numerous mouse transgenic lines … human APP transgenes
result in the deposition of Aβ peptide, similar but not identical to the Aβ peptide of human

[HTML][HTML] A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research

PL De Jager, Y Ma, C McCabe, J Xu, BN Vardarajan… - Scientific data, 2018 - nature.com
We initiated the systematic profiling of the dorsolateral prefrontal cortex obtained from a
subset of autopsied individuals enrolled in the Religious Orders Study (ROS) or the Rush …

What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus

…, Alzheimer's Disease Neuroimaging Initiative - Progress in …, 2014 - Elsevier
… of undetected disease. We review recent research on changes of the cerebral cortex and …
We argue that prominent cortical reductions are evident in fronto-temporal regions in elderly …

Neuropathologic correlates of human cortical proteins in Alzheimer disease and related dementias

L Yu, PA Boyle, AP Wingo, J Yang, T Wang… - Neurology, 2022 - AAN Enterprises
… We previously reported human cortical proteins that are implicated in Alzheimer dementia. …
proteins for underlying disease mechanisms, we investigated cortical protein associations …

Pathology of the insular cortex in Alzheimer disease depends on cortical architecture

DJ Bonthius, A Solodkin… - … of Neuropathology & …, 2005 - academic.oup.com
… This study demonstrated that the insular cortex is a prominent target of Alzheimer disease.
In many cases of Alzheimer disease, the insula is heavily burdened with NFTs, NPs, and Alz-…

Oxidative stress in the progression of Alzheimer disease in the frontal cortex

MA Ansari, SW Scheff - Journal of Neuropathology & …, 2010 - academic.oup.com
… increasing in a disease-dependent fashion. These correlations implicate an involvement of
oxidative stress in Alzheimer disease-related synaptic loss. Alzheimer disease, Free radicals, …

Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease

M Morawski, S Schilling, M Kreuzberger… - … of Alzheimer's …, 2014 - content.iospress.com
… Brains of Alzheimer’s disease (AD) patients are characterized in part by the formation of …
Here, we addressed the role of QC in AD pathogenesis in human cortex. Two sets of human

Characterization of l‐[3H]Nicotine Binding in Human Cerebral Cortex: Comparison Between Alzheimer's Disease and the Normal

DD Flynn, DC Mash - Journal of neurochemistry, 1986 - Wiley Online Library
… in the frontal cortex in Alzheimer's disease. In the infratemporal cortex, significant numbers
of … Replacement therapy directed at these sites may be warranted in Alzheimer's disease. …