… in pannexin linkages to disease support the notion that reduced levels of pannexin channels
can be protective against disease … these cases as each disease is considered individually. …

… play in the pathogenesis of several human diseases. It is crucial to understand the contribution
of these receptors and channels in physiological and pathological conditions, in order to …

… of these channels/receptors in the pathogenesis of several infectious diseases and the
possibilities of generating novel therapeutic approaches to reduce or prevent these diseases. …

… mechanistic structure and function and allowed to open the human pannexins channel biology.
… of pannexin 1 channels in various pathological diseases, to target novel therapeutics [4]. …

… that will allow for compensatory mechanisms to be assessed, the field will continue to further
elucidate the true nature of pannexin channels and their key roles in health and disease. …

… Pannexins (Panxs) form cell membrane channels and have … 1–3.1, 2 Pannexins are often
compared to connexins due to … hemichannels.4, 5 Pannexins act as conduits for adenosine …

… pannexin channels, with a focus on chemical pharmaceuticals and peptide mimetics that act
on pannexin 1… Considering the diverse roles for pannexins in regulating health and disease, …

… connexin and pannexin families of large-pore channels (7). … (ATP) release and nucleotide
permeation channel (18). It can be … between mutations in PANX1 and any human disease. …

… Pannexin-1 in cardiovascular diseases, including ischemia, arrhythmia, cardiac fibrosis, and
hypertension. Pannexin-… as an exciting, clinically relevant target in cardiovascular diseases. …

… So, we raise hypothesis that ATP release through the opening of pannexin-1 channel activates
P2Y receptors and P2X receptors, subsequent G proteins, triggering the accumulation of …