… a mouse model in a representative human derived head and neck cancer cell line for
preclinical … Ninety athymic NMRI mice were inoculated with human derived oral squamous cell …

… Since the early 1980s, human head and neck tumor fragments or squamous cell carcinoma
… model could be used to study head and neck cancer by implanting 130 human head and …

… of study for preclinical models of HNC go from domestic animals with spontaneous cancers,
because of their similarities with human HNSCC [28], to models based on carcinogenesis …

… as a tool in preclinical drug development with a focus on closed head injury (CHI) models in
… current experimental TBI models adequately reflect many aspects of human TBI. However, …

… models of traumatic brain injury (TBI) are used to elucidate primary and secondary sequelae
underlying human head injury … injury may underlie the discrepancy between preclinical and …

… More importantly, the tumor occurred in the hamster cheek pouch which represents an
immunodeficient area absent in humans, so this model did not mimic human HNSCC very well. …

… In particular, the development of three-dimensional models (bioreactors) of human glial …
the brain after traumatic injuries such as in stroke and head and spinal cord injury. These three-…

… freedom to position the human skull over the pig’s head, targeting at … to the human skull
was not tested with this animal model. For targets at substantially different locations in the human …

… was performed using 36 different porcine IT tracts connected to the same human plastinated
head. All porcine IT tracts were used within 24 hours after slaughter, except three (8.3%) …

… 6 preclinical experiments on 2 cadavers and 1 live mongrel dog and then applied the novel
techniques we developed to a human … to expand these techniques in our human clinical trial. …