… stress on p38 MAPK are not well understood. This study determined whether alterations
in the p38 MAPK pathway occurred prior to end-stage human heart failure. The p38 MAPK …

… In human and mammals, there are four isoforms in the p38 … , chronic activation of p38 MAPK
activity is viewed as pathological and pro-apoptotic, and inhibition of p38 MAPK activity is in …

… Kinase assay for p38 was performed with a p38 MAP kinase assay kit (Cell Signaling, Inc) …
p38 activity and TNFα, we determined the effect of TNFα treatment on p38 kinase activity in …

… p38 activity is regulated by phosphorylation at the end of a cascade composed of a MAPK
kinase (MKK) and an MKK kinase (… Human HF is characterized by the reduced expression or …

… activities thus, … ) of MAPK signaling in the heart or specifically in cardiac myocytes are still
largely unknown. To start to address this issue for the p38-MAPK pathway in the (rat) heart (…

… , p38-MAPK(s) and ERKs are expressed in the human heart and the activities of JNKs and
p38-MAPK(s) were increased in heart failure secondary to ischaemic heart disease. These …

… to control cell cycle is p38 MAP kinase activity. p38 regulates expression of genes required
… As shown in Figure 2C, p38 activity is very low in the fetal heart at this stage of development…

… increase in JNK activity could be observed after reperfusion. In conclusion, distinct activation
patterns of ERK1/2, p38, and JNK MAPKs can be observed in human heart during CABG. …

… At higher concentrations of the compound, p38 MAPK activity may be more … Human
mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart…

… on Ser 423 and Tyr 431 was p38-MAPK-dependent and hence … of TAK1 activity, whereby
p38 activity inhibits TAK1, through … of human p38α resulted in high intrinsic activity independent …