… multiprotein signaling complexesthat are assembled when FcϵRI and other Ag receptors
are engaged, newinformation on human receptor structures and tissue distribution, and the …

… IgE to its high-affinity receptor. We have solved the X-ray crystal structure of the antibody-binding
domains of the human IgE receptor … of the high affinity immunoglobulin E receptor alpha …

… human there is crosstalk between IgE- and IgG-mediated cellular activation. In the rodent,
the IgE Fc region can bind to two classes of low-affinity … IgE does not bind to FcγR in humans, …

The last time the high affinity receptor for IgE (Fc. RI) was explicitly reviewed in these … receptor
functions. The application of molecular genetic techniques to the analysis of the receptor …

… immunoglobulin E (IgE) comprising C,2, C,3, and C,4 domains is sufficient for binding to the
a chain of the high affinity IgE-Fc receptor … FccRIa with high affinity, various regions of the IgE-…

… extracellular antibody-binding portion of the human high-affinity IgE receptor, Fc" RI↵, has …
" RI↵ molecule presents a large convex surface to its IgE ligand. The most remarkable aspect …

… and functional expression of a chimeric human LY subunit. The data demonstrate that high
affinity IgE binding is localized to the extracellular domain of the human o( subunit and does …

… Therefore, we have developed an assay for canine IgE which uses a recombinant form of
the extracellular part of the alpha chain of the human high affinity IgE receptor (FcεRIα). …

… The high affinity receptor structure The human high affinity IgE receptor exists as a (hetero-)
trimer or tetramer on the surface of mast cells and basophils. The tetramer contains an α-…

… blocking the binding ofhuman IgE to human cells has discouraged … such research on human
igE receptors will hopefully … in tranfected cells of high affinity IgE receptor. Nature 1989; 337:…