[HTML][HTML] From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma

V Ratushny, MD Gober, R Hick… - The Journal of …, 2012 - Am Soc Clin Investig
… One recent observation in a human keratinocyte cell line (HaCaT cells) demonstrated
that the Fyn kinase is an effector of oncogenic Ras (61). In these studies, oncogenic Hras …

Insulin-like growth factors are mitogenic for human keratinocytes and a squamous cell carcinoma

EK Neely, VB Morhenn, RL Hintz, DM Wilson… - Journal of investigative …, 1991 - Elsevier
… N ormal adult human keratinocytes in monolayer culture and SCL-1, a skin-derived
squamous-cell carcinoma cell line, were investigated for the expression of receptors for insulinlike …

Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer

JE Dazard, H Gal, N Amariglio, G Rechavi, E Domany… - Oncogene, 2003 - nature.com
cells into squamous carcinoma cells (SCC), we compared the response to ultraviolet B
radiation (UVB) of normal human epidermal keratinocytes (… genes in keratinocytes fall into three …

E2F7 can regulate proliferation, differentiation, and apoptotic responses in human keratinocytes: implications for cutaneous squamous cell carcinoma formation

L Endo-Munoz, A Dahler, N Teakle, D Rickwood… - Cancer research, 2009 - AACR
… Given the association of E2F7b with growth inhibition in human keratinocytes, we examined
whether E2F7a or E2F7b was preferentially expressed in KSCs, which we have shown …

Detection of transforming growth factor alpha in normal, malignant, and hyperproliferative human keratinocytes.

AB Gottlieb, CK Chang, DN Posnett, B Fanelli… - The Journal of …, 1988 - rupress.org
… normal and malignant keratinocytes. Formalin-… Keratinocytes in eight nodular basal cell
carcinomas (a and b), one morpheic basal cell carcinoma (d), and one squamous cell carcinoma

Specific betapapillomaviruses associated with squamous cell carcinoma of the skin inhibit UVB-induced apoptosis of primary human keratinocytes

L Struijk, E van der Meijden… - Journal of general …, 2008 - microbiologyresearch.org
… Primary human keratinocytes transduced with E6 and E7 of … HPV8- and HPV20-expressing
keratinocytes in particular … when expressed in primary human keratinocytes. Infections with …

[HTML][HTML] XPC silencing in normal human keratinocytes triggers metabolic alterations that drive the formation of squamous cell carcinomas

HR Rezvani, AL Kim, R Rossignol, N Ali… - The Journal of …, 2011 - Am Soc Clin Investig
… Taken together, our results demonstrate that XPC silencing in normal human keratinocytes
leads to altered metabolism, which resembles the metabolic signature of most cancer cells. …

The genetic basis of human keratinocyte immortalisation in squatnous cell carcinoma development: The role of telomerase reactivation

EK Parkinson, RF Newbold, WN Keith - European Journal of Cancer, 1997 - Elsevier
… the immortal phenotype in a naturally occuring human tumour, we established keratinocyte
cultures from all stages of head and neck squamous cell carcinoma development (SCC-HN) …

TRPC channels determine human keratinocyte differentiation: new insight into basal cell carcinoma

B Beck, V Lehen'kyi, M Roudbaraki, M Flourakis… - Cell calcium, 2008 - Elsevier
… Indeed, our study is the first to characterize I SOC in human keratinocytes. Biophysical
characteristics of keratinocyte I SOC , including pharmacology and ion selectivity, were similar to …

Production of interleukin-1 and interleukin-6 by human keratinocytes and squamous cell carcinoma cell lines

M Partridge, D Chantry, M Turner, M Feldman - Journal of investigative …, 1991 - Elsevier
… on a wide range of cell types (reviewed in [7]) … keratinocytes [8] and IL-6 by keratinocyte
cell lines [9]. In this paper we confirm that cultured keratinocytes and squamous cell carcinoma (…