Production of human lactoferrin and lysozyme in the milk of transgenic dairy animals: past, present, and future
CA Cooper, EA Maga, JD Murray - Transgenic research, 2015 - Springer
… human milk, multiple lines of transgenic dairy animals that produce either human lactoferrin
or human … engineered dairy animals that produce either recombinant lactoferrin or lysozyme …
or human … engineered dairy animals that produce either recombinant lactoferrin or lysozyme …
Production of human lactoferrin in animal milk
IL Goldman, SG Georgieva, YG Gurskiy… - … and Cell Biology, 2012 - cdnsciencepub.com
… The expression constructs of the human lactoferrin (hLf) gene that were used for
producing transgenic animals. Two copies of the insulator are indicated with crosses; the β-casein …
producing transgenic animals. Two copies of the insulator are indicated with crosses; the β-casein …
Consumption of transgenic cows' milk containing human lactoferrin results in beneficial changes in the gastrointestinal tract and systemic health of young pigs
CA Cooper, KM Nelson, EA Maga, JD Murray - Transgenic research, 2013 - Springer
… The results from this study show that feeding milk from transgenic cows containing recombinant
human lactoferrin improved GI and immune health and potentially increased the pigs’ …
human lactoferrin improved GI and immune health and potentially increased the pigs’ …
Expression of human lactoferrin in milk of transgenic mice
GJ Platenburg, EPA Kootwijk, PM Kooiman… - Transgenic …, 1994 - Springer
… A suitable way to meet these criteria is expression via milk of transgenic dairy animals. Since
… hLF expressed in milk of transgenic animals are similar to those of human milk-derived LF. …
… hLF expressed in milk of transgenic animals are similar to those of human milk-derived LF. …
Expression of active recombinant human lactoferrin in the milk of transgenic goats
J Zhang, L Li, Y Cai, X Xu, J Chen, Y Wu, H Yu… - Protein Expression and …, 2008 - Elsevier
… The transgenic animals, integrated with the transgene, were then identified with polymerase
… The goats carrying hLf cDNA were mated with nontransgenic animals to produce transgenic …
… The goats carrying hLf cDNA were mated with nontransgenic animals to produce transgenic …
Characterization of recombinant human lactoferrin secreted in milk of transgenic mice
JH Nuijens, PHC van Berkel, MEJ Geerts… - Journal of Biological …, 1997 - ASBMB
… Human lactoferrin (hLF) is an iron-binding protein involved in host defense against infection
and severe inflammation. Transgenic mice were produced harboring either hLF cDNA or …
and severe inflammation. Transgenic mice were produced harboring either hLF cDNA or …
Large scale production of recombinant human lactoferrin in the milk of transgenic cows
PHC Van Berkel, MM Welling, M Geerts… - Nature …, 2002 - nature.com
… report on the generation of transgenic cows expressing recombinant human lactoferrin (rhLF)
in their milk, and on the properties of rhLF as compared with natural hLF from human milk. …
in their milk, and on the properties of rhLF as compared with natural hLF from human milk. …
Human lactoferrin transgenic rabbits produced efficiently using dimethylsulfoxide–sperm-mediated gene transfer
L Li, W Shen, L Min, H Dong, Y Sun… - Reproduction, Fertility …, 2006 - CSIRO Publishing
… Transgenic animal mammary gland bioreactors are used to produce recombinant proteins.
… the human lactoferrin (LF) gene was cloned and tissue-expressed in the glands of transgenic …
… the human lactoferrin (LF) gene was cloned and tissue-expressed in the glands of transgenic …
The effect of recombinant human lactoferrin from the milk of transgenic cows on Salmonella enterica serovar typhimurium infection in mice
J Wu, Y Hu, C Du, J Piao, L Yang, X Yang - Food & function, 2016 - pubs.rsc.org
… Given this beneficial effect, transgenic approaches have been used to produce lactoferrin. …
effect of recombinant human lactoferrin (rhLF) from the milk of transgenic cows on Salmonella …
effect of recombinant human lactoferrin (rhLF) from the milk of transgenic cows on Salmonella …
Large-scale production of recombinant human lactoferrin from high-expression, marker-free transgenic cloned cows
M Wang, Z Sun, T Yu, F Ding, L Li, X Wang, M Fu… - Scientific Reports, 2017 - nature.com
… bioreactor is attributable to the pronuclear microinjection technique used and the long
waiting period required to establish transgenic animal lines 5 . Although our group has recently …
waiting period required to establish transgenic animal lines 5 . Although our group has recently …
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