… and in such cases it is difficult to estimate the dose of drug which might be ingested by a …
of drug distribution into human milk from known physicochemical prop. er1ies of Ihe drug. …

… on the distribution of mebendazole and pyrantel embonate into human milk, both drugs
are poorly absorbed from the gastrointestinal tract and their distribution into human milk is …

… Drug Distribution-The present study concerns the distribution of drugs within human milk …
However, some comments on the relevance of this study to plasma/milk distribution may be …

… drug categories have been selected for review of the known literature on their distribution into
human breast milk… prediction of the distribution of related drugs into breast milk. This paper …

… into human milk, and the presence of a drug in human milk may not … distribution, low
maternal serum protein binding, and high lipid solubility, facilitate drug excretion into human milk…

… milk, the milk to plasma concentration ratio (M/P), has not been determined in vivo in humans
for most drugs… monolayers, assessment of drug binding to plasma and milk protein and lipid…

… The three main constituents of breast milk which are important for drug distribution are the
aqueous itself, protein and fat (Table 3). Variations in the concentrations of these components …

… drug transfer into human milk in order to assess the safety of breastfeeding during maternal
ingestion of the drug. … The drug is metabolized to norfluoxetine which has a much longer half-…

… The maternal plasma and milk drug concentrations were sufficiently high that calculated
dose of V and ODV approached the notional 10%‘level of concern’ for intake of drugs in milk [14]…

… milk [6]. In the present study we have quantified the extent of the distribution of sumatriptan
in human milk, … the exposure risk for the suckling infant of a migraineur treated with the drug. …