Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss

RR Ager, JL Davis, A Agazaryan, F Benavente… - …, 2015 - Wiley Online Library
… We previously reported that intrahippocampal transplantation of murine neural stem cells
(… neuronal loss. These promising findings prompted us to examine a human neural stem cell

Laminin enhances the growth of human neural stem cells in defined culture media

PE Hall, JD Lathia, MA Caldwell, C Ffrench-Constant - BMC neuroscience, 2008 - Springer
Human neural stem cells (hNSC) have the potential to provide novel cell-based therapies for
… In vivo, stem cells reside in distinct microenvironments or niches that are responsible for the …

Human neural stem cells induce functional myelination in mice with severe dysmyelination

N Uchida, K Chen, M Dohse, KD Hansen… - Science translational …, 2012 - science.org
… We show that purified, expanded, and banked fetal human neural stem cells generate … to
extend the potential window for human CNS stem cell therapy to patients with myelin disorders …

Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells

DE Redmond Jr, KB Bjugstad… - Proceedings of the …, 2007 - National Acad Sciences
Stem cells have been widely assumed to be capable of replacing lost or damaged cells
in a … We report that undifferentiated human neural stem cells (hNSCs) implanted into 1-methyl-4-…

Region-specific generation of cholinergic neurons from fetal human neural stem cells grafted in adult rat

P Wu, YI Tarasenko, Y Gu, LYM Huang… - Nature …, 2002 - nature.com
… -term mitogen-expanded human stem cells. As these neurons … For example, human stem
cell–derived cholinergic neurons … -expanded primary fetal human neural stem cells (hNSCs) to …

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

S Duan, G Yuan, X Liu, R Ren, J Li, W Zhang… - Nature …, 2015 - nature.com
… transformation of human neural stem cells (NSCs), but not mesenchymal stem cells. PTEN-…
and instates ‘aggressiveness’ in human glioblastoma stem cells. In a large clinical database…

Attomole quantification and global profile of RNA modifications: Epitranscriptome of human neural stem cells

M Basanta-Sanchez, S Temple, SA Ansari… - Nucleic acids …, 2016 - academic.oup.com
human pluripotent stem cell-derived, neural stem cells. A wide variety of RNA modifications
were detected at levels as low as 0.0023 pg/μl, 64.09 attomoles. These results illustrate the …

Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease

T Yasuhara, N Matsukawa, K Hara, G Yu… - Journal of …, 2006 - Soc Neuroscience
… In this study, we evaluated human HB1.F3 neural stem cells (NSCs) as graft source for PD.
… F3 cells, a human fetal-derived neural stem cell line, as described previously in detail, were …

A novel, immortal, and multipotent human neural stem cell line generating functional neurons and oligodendrocytes

L De Filippis, G Lamorte, EY Snyder, A Malgaroli… - Stem …, 2007 - academic.oup.com
… type cell lines currently available is insufficient. Here we report the establishment of a stable
human neural stem cell line (immortalized human … These cells demonstrate three- to fourfold …

Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia

K Chu, M Kim, KI Park, SW Jeong, HK Park, KH Jung… - Brain research, 2004 - Elsevier
Stem cell transplantation may recover functional deficit by replacing damaged brain. In this
study, we attempted to test whether the human neural stem cells … viabilities of human NSCs in …