Induction of human neuronal cells by defined transcription factors

ZP Pang, N Yang, T Vierbuchen, A Ostermeier… - Nature, 2011 - nature.com
… of transcription factors could induce a neuronal fate in human … have identified a combination
of transcription factors that are capable of converting human fibroblasts directly into neurons. …

Transcription factor-based strategies to generate neural cell types from human pluripotent stem cells

I Canals, E Quist, H Ahlenius - Cellular Reprogramming, 2021 - liebertpub.com
… to study human neural cells; however, in combination with animal studies and observations
in postmortem tissue, they represent powerful tools to understand functionality of brain cells

Human long non‐coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors

SY Ng, R Johnson, LW Stanton - The EMBO journal, 2012 - embopress.org
… suggests that the lncRNAs play a key role in neural cell fate specification. … identified lncRNAs
essential for the maintenance of pluripotency and neuronal differentiation in human cells

Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS

I Jakovcevski, N Zecevic - Journal of Neuroscience, 2005 - Soc Neuroscience
human brain. In this study, we examine whether the expression of Olig1 and Olig2 transcription
factors … the onset and developmental progression of OL lineage in the human fetal CNS. …

[HTML][HTML] The human transcription factors

SA Lambert, A Jolma, LF Campitelli, PK Das, Y Yin… - Cell, 2018 - cell.com
… to regulation of transcription. This review considers how TFs are identified and functionally
characterized, principally through the lens of a catalog of over 1,600 likely human TFs and …

Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene

P Pruunsild, M Sepp, E Orav, I Koppel… - Journal of …, 2011 - Soc Neuroscience
… of this promoter by neuronal activity. Together, the results of this study … identified the cis-elements
and transcription factors regulating neuronal activity-dependent transcription of human

Overexpression of basic helix-loop-helix transcription factors enhances neuronal differentiation of fetal human neural progenitor cells in various ways

A Serre, EY Snyder, J Mallet… - Stem Cells and …, 2011 - liebertpub.com
… Because some of these markers can have expression patterns that extend beyond one neural
cell type, often dual marker expression was used in this study to clarify specific neural cell

Neuronal transcription factors induce conversion of human glioma cells to neurons and inhibit tumorigenesis

J Zhao, H He, K Zhou, Y Ren, Z Shi, Z Wu, Y Wang… - 2012 - journals.plos.org
… It is well known that neurons are terminally differentiated cells … glioma cells to become neurons
by introducing transcription factors. … of induced neuronal (iN) cells from glioma cells by the …

Transcription factor programming of human ES cells generates functional neurons expressing both upper and deep layer cortical markers

G Miskinyte, M Grønning Hansen, E Monni, M Lam… - PLoS …, 2018 - journals.plos.org
cells have been incompletely characterized. Here we have used transcription factor (TF) …
aim to induce rapid differentiation of human ES cells to layer-specific cortical neurons (hES-iNs). …

… generation of functional dopaminergic neurons from human induced pluripotent stem cells through a single-step procedure using cell lineage transcription factors

I Theka, M Caiazzo, E Dvoretskova… - Stem cells …, 2013 - academic.oup.com
… We previously reported that mouse and human fibroblasts can be directly reprogrammed
into dopaminergic-like neuronal cells by the combined expression of the three cell lineage TFs …