[HTML][HTML] Zika virus disrupts molecular fingerprinting of human neurospheres

PP Garcez, JM Nascimento, JM de Vasconcelos… - Scientific reports, 2017 - nature.com
… molecular consequences of ZIKV to human brain development are still not … in human
neurospheres derived from induced pluripotent stem (iPS) cells infected with the strain of Zika virus

[HTML][HTML] Zika virus impairs neurogenesis and synaptogenesis pathways in human neural stem cells and neurons

L Rosa-Fernandes, FR Cugola, FB Russo… - Frontiers in cellular …, 2019 - frontiersin.org
Zika Virus (ZIKV) is a flavivirus first isolated in non-human primate in 1947 in the … quantified
from human neurospheres reveals different protein regulation among viral strains. (C) …

[HTML][HTML] Differential responses of human fetal brain neural stem cells to Zika virus infection

EL McGrath, SL Rossi, J Gao, SG Widen, AC Grant… - Stem cell reports, 2017 - cell.com
Zika virus (ZIKV) infection causes microcephaly in a subset of infants born to infected
pregnant mothers. It is unknown whether human individual differences contribute to differential …

[HTML][HTML] Zika Virus Infection Alters the Circadian Clock Expression in Human Neuronal Monolayer and Neurosphere Cultures

TYV de Lima Cavalcanti, MC Lima… - Cellular and Molecular …, 2024 - Springer
… In vitro models of Zika virus (ZIKV) neuronal infection. Human neuroprogenitor cells were
cultured as monolayer and neurospheres and infected by ZIKV. Monolayer-cultured cells …

Zika virus strains and dengue virus induce distinct proteomic changes in neural stem cells and neurospheres

JM Nascimento, D Gouvêa-Junqueira, GS Zuccoli… - Molecular …, 2022 - Springer
viruses are able to infect cells (Fig. 1B) and we observe that these infections are present in
neurosphere … Therefore, after 3 days, the effects of infection of NSCs and neurospheres with …

[HTML][HTML] Western Zika virus in human fetal neural progenitors persists long term with partial cytopathic and limited immunogenic effects

NW Hanners, JL Eitson, N Usui, RB Richardson… - Cell reports, 2016 - cell.com
… The recent Zika virus (ZIKV) outbreak in the Western hemisphere is associated with severe
… stem-cell-derived human neural progenitors (hNPs), neurospheres, and organoids with …

[HTML][HTML] Zika virus NS4A and NS4B proteins deregulate Akt-mTOR signaling in human fetal neural stem cells to inhibit neurogenesis and induce autophagy

Q Liang, Z Luo, J Zeng, W Chen, SS Foo, SA Lee, J Ge… - Cell stem cell, 2016 - cell.com
… The current widespread outbreak of Zika virus (ZIKV) infection … Here, we show that ZIKV
infection of human fetal neural stem … Zika virus impairs growth in human neurospheres and brain …

[PDF][PDF] Zika Virus Impairs Neurogenesis and Synaptogenesis Pathways in Human Neural Stem Cells and Neurons

D Gonzalez-Dunia, J Rossignol, CE Malnou… - Front. Cell …, 2019 - academia.edu
Zika Virus (ZIKV) is a flavivirus first isolated in non-human primate in 1947 in the … quantified
from human neurospheres reveals different protein regulation among viral strains. (C) …

[HTML][HTML] Zika virus infection induces cranial neural crest cells to produce cytokines at levels detrimental for neurogenesis

NL Bayless, RS Greenberg, T Swigut, J Wysocka… - Cell host & …, 2016 - cell.com
Zika virus infection in pregnant women in Rio de Janeiro—… Zika virus impairs growth in
human neurospheres and brain … Expression analysis highlights AXL as a candidate Zika virus

Zika virus impairs growth in human neurospheres and brain organoids

PP Garcez, EC Loiola, R Madeiro da Costa, LM Higa… - Science, 2016 - science.org
… the viral epidemic … in human neural stem cells growing as neurospheres and brain organoids.
Using immunocytochemistry and electron microscopy, we showed that ZIKV targets human