Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.

WD Tilley, G Buchanan, TE Hickey, JM Bentel - … Association for Cancer …, 1996 - AACR
… Abstract Progression to androgen-independent growth of human prostate cancers may be
mediated by alterations in the structure and/or expression of the androgen receptor (AR) gene…

LNCaP progression model of human prostate cancer: Androgenindependence and osseous metastasis

GN Thalmann, RA Sikes, TT Wu, A Degeorges… - … Prostate, 2000 - Wiley Online Library
human prostate cancer. Evidence suggests that androgen-deprivation may facilitate
androgenindependent progression and acquisition of metastatic potential by prostate cancer cells in …

Mechanisms of the development of androgen independence in prostate cancer

A So, M Gleave, A Hurtado-Col, C Nelson - World journal of urology, 2005 - Springer
cancer is of … the prostate cancer cell to an androgen independent phenotype is a
complex process that involves selection and outgrowth of pre-existing clones of androgen-independent

Molecular alterations during progression of prostate cancer to androgen independence

P Saraon, K Jarvi, EP Diamandis - Clinical chemistry, 2011 - academic.oup.com
… in the progression to androgen independence remain largely … mechanisms of androgen
independence in prostate cancer (8… the evolution and progression of prostate cancer, as well as …

Prostate cancer: molecular biology of early progression to androgen independence.

MD Sadar, M Hussain… - … -Related Cancer, 1999 - erc.bioscientifica.com
… The androgen-independent regulation of PSA gene … model of human prostate cancer. The
data, as presented in Fig.4, demonstrate the effects of continuous versus intermittent androgen

Transition to androgen-independence in prostate cancer

D Navarro, OP Luzardo, L Fernández, N Chesa… - The Journal of steroid …, 2002 - Elsevier
… Whether these finding operate in human prostatic cancer remain to be demonstrated, but if
so they … the complex cross-talking operating in the hormone resistant prostatic cancer cells. …

Prostate cancer cell cycle regulators: response to androgen withdrawal and development of androgen independence

DB Agus, C Cordon-Cardo, W Fox… - … the National Cancer …, 1999 - academic.oup.com
prostate cancers after androgen withdrawal, we studied cell cycle regulator changes in the
CWR22 human prostate cancerandrogen withdrawal and after the development of androgen

The androgen receptor and mechanisms for androgen independence in prostate cancer

J Javidan, AD Deitch, XB Shi… - Cancer …, 2005 - Taylor & Francis
… for Androgen Independent Prostate Cancer Growth Human prostate cancer generally is
sensitive to androgens … , followed by relapse to an androgen-independent state. The molecular …

Mechanisms of prostate cancer progression to androgen independence

MJ McPhaul - Best Practice & Research Clinical Endocrinology & …, 2008 - Elsevier
human prostate cancer and prostate cancer models. Much of this information is consistent with
the androgen … being a central element in prostate cancer development and progression. A …

Androgen receptor: a key molecule in the progression of prostate cancer to hormone independence

ME Taplin, SP Balk - Journal of cellular biochemistry, 2004 - Wiley Online Library
… the cancers are described as androgen-independent or … % of men with androgen-independent
prostate cancer but most … of growth in androgen-independent prostate cancer and that an …