Direct renin inhibition with aliskiren in hypertension and target organ damage
DN Mu, FC Luft - Clinical Journal of the American Society of …, 2006 - journals.lww.com
… A novel animal model of high human renin hypertension in the rat attest to target organ …
therapy all lead to sharp increases in plasma renin activity, aliskiren offers a novel circumvention. …
therapy all lead to sharp increases in plasma renin activity, aliskiren offers a novel circumvention. …
Inhibition of the renin–angiotensin system and target organ protection
J Iwanami, M Mogi, M Iwai, M Horiuchi - Hypertension Research, 2009 - nature.com
… basic mechanisms of target organ damage induced by RAS in each organ and the effect of
… (ARBs), on target organ damage are discussed, together with the recent paradigm of RAS. …
… (ARBs), on target organ damage are discussed, together with the recent paradigm of RAS. …
Signal transduction of the (pro) renin receptor as a novel therapeutic target for preventing end-organ damage
H Funke-Kaiser, FS Zollmann, JH Schefe… - Hypertension …, 2010 - nature.com
… Binding of renin to this receptor increases the catalytic activity of renin by about four- to … I)
in solution, gains enzyme activity comparable to that of renin by binding to the (P)RR, that is, the …
in solution, gains enzyme activity comparable to that of renin by binding to the (P)RR, that is, the …
Update on tissue renin–angiotensin systems
M Bader, D Ganten - Journal of Molecular Medicine, 2008 - Springer
… human renin infusion, indicating that the SFO is of pivotal importance for the central pressor
effect of Ang II. When in transgenic animals carrying human renin and human AOGEN, the …
effect of Ang II. When in transgenic animals carrying human renin and human AOGEN, the …
Low-dose renin inhibitor and low-dose AT1-receptor blocker therapy ameliorate target-organ damage in rats harbouring human renin and angiotensinogen genes
R Dechend, E Shagdarsuren, P Gratze… - Journal of the renin …, 2007 - journals.sagepub.com
… Our data show that minimal doses of aliskiren, a new human renin inhibitor, provided
target organ protection without significant effects on BP, as did the AT1-receptor blocker. The …
target organ protection without significant effects on BP, as did the AT1-receptor blocker. The …
Human skin: source of and target organ for angiotensin II
UM Steckelings, T Wollschläger, J Peters… - Experimental …, 2004 - Wiley Online Library
… In the case that skin is indeed a target organ for Ang II, it … angiotensinogen by the enzymes
renin (resulting in Ang I) and … of angiotensinogen, renin and ACE in diverse human cutaneous …
renin (resulting in Ang I) and … of angiotensinogen, renin and ACE in diverse human cutaneous …
Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy
M Bader - Annual review of pharmacology and toxicology, 2010 - annualreviews.org
… the cardiovascular actions of the classical RAAS in target organs (35). … carrying human
renin and human angiotensinogen, water intake decreased (67). Thus, the subfornical organ is of …
renin and human angiotensinogen, water intake decreased (67). Thus, the subfornical organ is of …
New developments in renin and hypertension.
NJ Samani - BMJ: British Medical Journal, 1991 - ncbi.nlm.nih.gov
… The renin-angiotensin system plays an important part in cardiovascular … II on target organs
such as the kidneys, the blood vessels, and the adrenals.' Standard teaching is that renin …
such as the kidneys, the blood vessels, and the adrenals.' Standard teaching is that renin …
Blockade of the renin-angiotensin-aldosterone system: effects on hypertensive target organ damage
AM Grandi, AM Maresca - Cardiovascular & Hematological …, 2006 - ingentaconnect.com
… drugs have been demonstrated to protect against target organ damage, reversing or preventing
its … target organ damage. THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (RAAS) …
its … target organ damage. THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (RAAS) …
Prorenin/renin receptor, signals, and therapeutic efficacy of receptor blocker in end-organ damage
T Inagami, A Ichihara - Current hypertension reports, 2007 - Springer
… to human mesangial cells where prorenin and renin activated ERK 1… [14] observed that
recombinant human renin stimulated … , and PAI-1 in rat and human mesangial cells. Collagen and …
recombinant human renin stimulated … , and PAI-1 in rat and human mesangial cells. Collagen and …
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