8 天前 - … systems, or the renin–angiotensin–aldosterone system). Dysregulated ROS
production (oxidative stress) is a hallmark of hypertension in humans and experimental models. Of …

15 天前 - … -renin hypertension is mediated by excess mineralocorticoid receptor (MR) activation
and that targeted … to investigate whether targeted treatment in low-renin hypertension with …

70 天前 - … Four-week-old dTGR (transgenic for human renin and angiotensinogen) were
treated with oral Vancomycin (Vanco), Polymyxin B (Poly) or Vehicle (Veh) for 3 weeks. Seven-…

70 天前 - … AZD5462 administered orally to NHPs and healthy human participants elicited an
early and sustained dose-dependent increase in plasma renin concentration, and in humans …

142 天前 - … organ outside of the adrenal cortex. To explore this possibility, we developed a vector
encoding human 21-… Aldosterone and renin levels normalized, and corticosterone levels …

171 天前 - … Consequently, we conducted renin IHC on sequential sections of the same … renin
(ie, renin and prorenin), mirroring the method employed for determining overall plasma renin …

204 天前 - … human tissues, it is understandable that VDD is associated with a variety of disparate
changes in multiple organs, … 1 The activation of the renin-angiotensin-aldosterone system, …

260 天前 - The renin–angiotensin system plays a crucial role in the regulation of blood pressure.
Activation of the angiotensin II (Ang II)–Ang II type 1 receptor (AT1R) signaling pathway …

274 天前 - … We developed an AngII peptide intending to assess whether the peptide of the
renin–angiotensin system holds the ability to target AT1 receptor-overexpressing breast cancer …

339 天前 - … Simultaneous use of ACE inhibitors, ARBs, and/or renin inhibitors is not recommended
… in controlling blood pressure and target organ damage with reduced risk of side effects. …