… mice expressing human renin from an artificial chromosome have demonstrated that the
renal enhancer of the human renin gene is dispensable for the stimulation of renin gene …

… It has been suggested that lipophilic agents might be more effective than drugs that are more
hydrophilic in lowering blood pressure and protecting target organs. However, there is little …

… Similarly, knockdown of the (P)RR in the SFO of human renin and angiotensinogen
double transgenic hypertensive mice significantly reduced blood pressure with concomitant …

… the memory of the renin phenotype and the intrinsic plasticity of renin cells to switch identity
to preserve homeostasis. Finally, we describe how permanent changes in renin cell fate lead …

… In the mouse and rat fetus the expression of Ago in the yolk sac, liver, and brain15 and of
renin … The AT1 receptor is expressed in the rat in classical target organs of Angil, such as liver, …

… Because dTGR produce both rat and human renin, we co-infused rat (NH2-RILLKKMPSV-COOH;
Biosynthan, Berlin, Germany) and human (NH2-RIFLKRMPSI-COOH; Biosynthan) …

… organ functions and their responses to therapeutic intervention. Imaging of the intra-renal
renin content and enzymatic activity of renin … cellular components of renin release signals and …

… pressure through its systemic synthesis via the renin-angiotensin-aldosterone cascade. It …
lead to restructuring in these target organs, with consequent organ dysfunction. Additionally, …

… renin system in in vitro conditions, aliskiren (direct renin inhibitor) increases the half life of
renin and prorenin in rat vascular smooth muscle cells overexpressing human (P)RR [13]. …

The renin-angiotensin system (RAS) is a coordinated hormonal cascade in the control of
cardiovascular, renal, and adrenal function that governs body fluid and electrolyte balance, as …