… is totally independent of renin, as renin is not expressed in … performed, and Drosophila
and Hydra do not have renin. … in human glioblastoma and have shown that inhibition of renin …

… that lead to progressive target organ damage in the heart, … the risk of progressive target
organ damage in patients with … may produce improved target organ protection as witnessed …

… that, in the subfornical organ of the human brain, the (pro)renin receptor is expressed in …
renin receptor immunoreactivity in the subfornical organ is increased in hypertensive humans …

… This study describes the pharmacological properties of a novel sGC stimulator riociguat (BAY
63-2521) and its effects on target organ damage in low-renin and high-renin rat models of …

… For example, in the loop near the NH2-terminus, residues Thr7 to Tyr'5 [the numbering
throughout is based on our alignment of the human renin sequence with that of porcine pepsin (26…

… as human, mice, rats, dogs, and zebra fish. Its structure is similar to that of pepsinogen, a
related aspartyl protease, suggesting a common evolutionary origin (135). The human renin …

… renin promoter. Transgenic mice carrying a genomic human renin construct showed no cardiac
renin … control of its own promoter expressed high levels of renin mRNA in the heart (549). …

… Studies with the specific AT 2 receptor agonist, compound 21 (C21) have highlighted AT 2
's role to counteract the detrimental effects of AT 1 receptor activation on target organ damage. …

… These effects may also contribute to target organ damage independent of the effects of Ang
… formed by human renin if it entered or were taken up by cardiomyocytes expressing human …

… The dysregulation of renin-angiotensin-system (RAS) plays a pivotal role in hypertension
and in the development of the related target organ damage (TOD). The main goal of treating …