… Evidence suggests that virtually every organ system in the human body possesses a local
renin–angiotensin system (RAS). These local systems seem to be independently regulated …

… and related target organ damage are caused by inappropriate activation of the intrarenal
renin system [13,15••]. The continuous activation of the intrarenal renin system results in …

… As summarized in Table 1, in the placebotreated group, the circulating renin–angiotensin …
Both the ACE inhibitor and the ARB suppressed blood pressure and increased renin activity, …

… The lowest concentrations of renin and prorenin shown to stimulate signal … pmol/L of human
renin for stimulation of TGF-β1 production by human mesangial cells, 8 20 pmol/L of human …

… regulating hypertensive target organ damage through the generation of murine Agtr1a −/−
bone marrow chimeras. The Tsukuba mouse harbors the human renin and angiotensinogen …

… used to target the activation of renin. The sorting of renin to the regulated secretory pathway
is not highly efficient in juxtaglomerular cells; only 25% of the synthesized renin is directed to …

… humans that renin may be undesirable and contribute both to hypertension and end-organ …
have failed to achieve target BP, and we have failed to ascertain the true benefits of …

… to target organ protection. In a study published in 2008, my research group used the same
participant inclusion criteria and low-salt intake approach to RAS activation described above (…

… For example, we reported previously that the human renin and human angiotensinogen
genes could fully complement lethality and renal defects in angiotensinogen-deficient mice.…

… as an intermediate in Wnt signalling independent of (pro)renin. In conclusion, (pro)renin-dependent
signalling is unlikely in non-(pro)renin synthesizing organs, and the (P)RR role in V-…