… Human studies suggest that excess aldosterone has a direct pro-inflammatory and fibrotic
effect, contributing to target organ degradation, which manifests itself in the development of …

… The enzyme renin has long been considerel clusively renal enzyme responsible for the …
sidered a peptide hormone with specific target organs. Since renin has been discovered to occur …

… There is increasing evidence that RAS inhibition may provide end-organ protection independent
of BP lowering. Two drug classes directly target angiotensin II through complementary …

… pointed out that renin-angiotensin system (RAS) activity may represent an ideal target for …
, for instance on the basis of the plasma renin profile, support the concept that an enhanced …

… local renin-angiotensin systems. In transgenic mice expressing the human renin gene, renin
mRNA … Rat and mouse brain and heart express very low levels of renin, and renin message …

… -fold more human renin … human renin cDNA and the complete human renin amino acid
sequence. We then discovered the genomic sequences of human renin and its substrate, human …

… the sequences and specificity of human and most nonprimate renins and angiotensinogens.
Human renin inhibitors are generally poor inhibitors of rat renin and this has precluded the …

… Of the 132 patients, 55 (41.7%) had target organ damage, … (58.3%) had no target organ
damage, including 61 males (79.2… plasma renin/angiotensin/aldosterone levels and target organ …

… (43) compared aliskiren and valsartan in preventing target organ damage in dTGR. Matched
6-week-old dTGR received either no treatment, low-dose or high-dose aliskiren, or low-…

… A The peptide enters the circulation and produces its effects at target organs located at
distance, eg vasculature and adrenal gland (endocrine). B After secretion, the peptide acts on its …