… organ protective effect tend to have relatively normal renin activity, whereas those models
in which HRP is ineffective tend to have high active renin … heart rate in human renin receptor …

… The kidney is the classic target organ of the circulating RAS. Variants of genes such as ACE,
angiotensinogen or AT1 receptor modulate activity and expression not only of components …

… a rise in plasma renin concentration by interfering with the negative feedback loop exerted
by Ang II on renin formation. In patients with diabetes and target organ damage, the plasma …

… renin is less effective in elevating of the blood pressure than crude substrate. This observation
led to a conclusion that renin is … renin gene in rats and humans, there are two renin coding …

… It is also known that angiotensin II exerts its effects at the cellular level through multiple
mechanisms of signal transduction that vary among target organs. For instance, in mesangial cells…

… with high renin and aldosterone levels but normotension and little evidence of target organ
… but suppressed renin and aldosterone levels exhibit substantial target organ damage ( 57 , …

… Oxidative stress damages target organs via multiple mechanisms. For example, lectinlike
oxidized low-density lipoprotein (LDL) receptor (LOX)1, a novel oxidized LDL (ox-LDL) …

… did not improve target organ damage in renovascular Goldblatt hypertensive rats. 2K1C
rats develop high renin, prorenin, and PRA leading to Ang II-dependent target organ damage. …

… The most classical view of the renin-angiotensin system (RAS) emphasizes its role as an
endocrine regulator of sodium balance and blood pressure. Renin mediates angiotensin I …

… mortality and morbidity through its effects on target organs like the brain, heart, … target organ
damage. In this review, we describe damages related to hypertension in these target organs …